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Journal of Chemical Information and Modeling|May 3, 2019
Conformation and Permeability: Cyclic Hexapeptide DiastereomersSatoshi Ono, Matthew R Naylor, Chad E Townsend, et al.
Journal of Medicinal Chemistry|October 4, 2016
Passive Membrane Permeability in Cyclic Peptomer Scaffolds Is Robust to Extensive Variation in Side Chain Functionality and Backbone GeometryAkihiro Furukawa, Chad E Townsend, Joshua Schwochert, et al.
Organic & Biomolecular Chemistry|September 9, 2020
Connecting the conformational behavior of cyclic octadepsipeptides with their ionophoric property and membrane permeabilityThomas Stadelmann, Govindan Subramanian, Sanjay Menon, et al.
Journal of Chemical Information and Modeling|October 21, 2021
Cyclosporin A: Conformational Complexity and ChameleonicitySatoshi Ono, Matthew R Naylor, Chad E Townsend, et al.
Journal of Medicinal Chemistry|August 27, 2015
Going Out on a Limb: Delineating The Effects of β-Branching, N-Methylation, and Side Chain Size on the Passive Permeability, Solubility, and Flexibility of Sanguinamide A AnaloguesAndrew T Bockus, Joshua A Schwochert, Cameron R Pye, et al.
Journal of the American Chemical Society|December 31, 2020
Geometrically Diverse Lariat Peptide Scaffolds Reveal an Untapped Chemical Space of High Membrane PermeabilityColin N Kelly, Chad E Townsend, Ajay N Jain, et al.
ACS Medicinal Chemistry Letters|September 17, 2020
Understanding and Improving the Membrane Permeability of VH032-Based PROTACsVictoria G Klein, Chad E Townsend, Andrea Testa, et al.
Journal of Medicinal Chemistry|January 7, 2017
Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug MoleculesCameron R Pye, William M Hewitt, Joshua Schwochert, et al.
Nature Communications|March 18, 2023
Amide-to-ester substitution as a stable alternative to N-methylation for increasing membrane permeability in cyclic peptidesYuki Hosono, Satoshi Uchida, Moe Shinkai, et al.
Journal of Medicinal Chemistry|November 6, 2018
Lipophilic Permeability Efficiency Reconciles the Opposing Roles of Lipophilicity in Membrane Permeability and Aqueous SolubilityMatthew R Naylor, Andrew M Ly, Mason J Handford, et al.
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