Showing results (21-30 of 42) with videos related to
Sort By:
Pageof 5
Heart Rhythm|September 27, 2019
High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variantsChai-Ann Ng, Matthew D Perry, Whitney Liang, et al.Plos One|January 21, 2011
The N-terminal tail of hERG contains an amphipathic α-helix that regulates channel deactivationChai Ann Ng, Mark J Hunter, Matthew D Perry, et al.American Journal of Human Genetics|June 10, 2022
A massively parallel assay accurately discriminates between functionally normal and abnormal variants in a hotspot domain of KCNH2Chai-Ann Ng, Rizwan Ullah, Jessica Farr, et al.Nature Communications|January 21, 2016
Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tensionCharles D Cox, Chilman Bae, Lynn Ziegler, et al.American Journal of Human Genetics|June 10, 2022
A calibrated functional patch-clamp assay to enhance clinical variant interpretation in KCNH2-related long QT syndromeConnie Jiang, Ebony Richardson, Jessica Farr, et al.The Journal of Physiology|March 10, 2016
Rescue of protein expression defects may not be enough to abolish the pro-arrhythmic phenotype of long QT type 2 mutationsMatthew D Perry, Chai Ann Ng, Kevin Phan, et al.Cardiovascular Research|October 20, 2019
Pharmacological activation of IKr in models of long QT Type 2 risks overcorrection of repolarizationMatthew D Perry, Chai-Ann Ng, Melissa M Mangala, et al.Medrxiv : the Preprint Server for Health Sciences|February 20, 2025
Calibrated Functional Data Decreases Clinical Uncertainty for Tier 1 Monogenic Disease: Application to Long QT SyndromeChai-Ann Ng, Matthew J O'Neill, Samskruthi R Padigepati, et al.The Canadian Journal of Cardiology|March 21, 2026
KCNH2 Duplication Variant (c.2164_2181dup) Associated with Sudden Cardiac Death in a Family with Congenital Long QT SyndromeAngela Ambrosio, Chai-Ann Ng, Lindsay Burnell, et al.Nature Communications|September 26, 2014
Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2Arash Sadrieh, Luke Domanski, Joe Pitt-Francis, et al.Pageof 5