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Bioorganic & Medicinal Chemistry Letters|May 14, 2011
Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535Allen J Duplantier, Mark A Dombroski, Chakrapani Subramanyam, et al.Bioconjugate Chemistry|July 15, 2016
Natural Product Splicing Inhibitors: A New Class of Antibody-Drug Conjugate (ADC) PayloadsSujiet Puthenveetil, Frank Loganzo, Haiyin He, et al.Molecular Cancer Therapeutics|July 6, 2022
Anti-Extra Domain B Splice Variant of Fibronectin Antibody-Drug Conjugate Eliminates Tumors with Enhanced Efficacy When Combined with Checkpoint BlockadeAndrea T Hooper, Kimberly Marquette, Chao-Pei Betty Chang, et al.Journal of Medicinal Chemistry|November 29, 2014
Discovery of cytotoxic dolastatin 10 analogues with N-terminal modificationsAndreas Maderna, Matthew Doroski, Chakrapani Subramanyam, et al.Journal of Medicinal Chemistry|May 21, 2010
Design of selective, ATP-competitive inhibitors of AktKevin D Freeman-Cook, Christopher Autry, Gary Borzillo, et al.Bioorganic & Medicinal Chemistry Letters|March 21, 2012
Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulatorsMartin Pettersson, Douglas S Johnson, Chakrapani Subramanyam, et al.Bioorganic & Medicinal Chemistry Letters|June 15, 2017
Novel 3-fluoro-6-methoxyquinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IVMark J Mitton-Fry, Steven J Brickner, Judith C Hamel, et al.ACS Medicinal Chemistry Letters|November 25, 2016
Optimization of Tubulysin Antibody-Drug Conjugates: A Case Study in Addressing ADC MetabolismL Nathan Tumey, Carolyn A Leverett, Beth Vetelino, et al.Journal of Medicinal Chemistry|January 17, 2014
Design, synthesis, and pharmacological evaluation of a novel series of pyridopyrazine-1,6-dione γ-secretase modulatorsMartin Pettersson, Douglas S Johnson, Chakrapani Subramanyam, et al.ACS Medicinal Chemistry Letters|May 26, 2015
Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic StabilityMartin Pettersson, Douglas S Johnson, John M Humphrey, et al.Pageof 4