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Journal of Medicinal Chemistry|October 15, 2011
Metabolism-directed design of oxetane-containing arylsulfonamide derivatives as γ-secretase inhibitorsAntonia F Stepan, Kapil Karki, W Scott McDonald, et al.Journal of Medicinal Chemistry|November 26, 2010
Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejectionMark E Flanagan, Todd A Blumenkopf, William H Brissette, et al.Bioorganic & Medicinal Chemistry Letters|August 21, 2007
Pyrimidine benzamide-based thrombopoietin receptor agonistsLawrence A Reiter, Chakrapani Subramanyam, Emilio J Mangual, et al.Bioorganic & Medicinal Chemistry Letters|March 23, 2005
Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14Julian A Blagg, Mark C Noe, Lilli A Wolf-Gouveia, et al.Bioorganic & Medicinal Chemistry Letters|April 10, 2013
Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IVMark J Mitton-Fry, Steven J Brickner, Judith C Hamel, et al.The Journal of Clinical Investigation|August 10, 2023
Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimer's disease phenotype in miceNathaniel L Gould, Gila R Scherer, Silvia Carvalho, et al.Journal of Medicinal Chemistry|March 17, 2012
Application of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active γ-secretase inhibitorAntonia F Stepan, Chakrapani Subramanyam, Ivan V Efremov, et al.ACS Medicinal Chemistry Letters|June 20, 2020
Characterization of Specific <i>N</i>-α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded LibraryPei-Pei Kung, Patrick Bingham, Benjamin J Burke, et al.Nature Chemical Biology|May 21, 2024
A chemical probe to modulate human GID4 Pro/N-degron interactionsDominic D G Owens, Matthew E R Maitland, Aliakbar Khalili Yazdi, et al.Journal of Medicinal Chemistry|June 7, 2024
Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's DiseaseMartin Pettersson, Douglas S Johnson, John M Humphrey, et al.Pageof 4