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Journal of Medicinal Chemistry|November 3, 2009
Synthetic mRNA splicing modulator compounds with in vivo antitumor activityChandraiah Lagisetti, Alan Pourpak, Tinopiwa Goronga, et al.Pharmacology Research & Perspectives|July 15, 2015
Pharmacodynamic assays to facilitate preclinical and clinical development of pre-mRNA splicing modulatory drug candidatesYihui Shi, Amanda S Joyner, William Shadrick, et al.Plos One|May 30, 2020
An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applicationsYihui Shi, Walter Bray, Alexander J Smith, et al.Scientific Reports|December 8, 2017
Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus EndonucleaseDiane Beylkin, Gyanendra Kumar, Wei Zhou, et al.Nucleic Acids Research|March 14, 2014
Sudemycin E influences alternative splicing and changes chromatin modificationsPaolo Convertini, Manli Shen, Philip M Potter, et al.Oncotarget|June 13, 2015
The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemiaSílvia Xargay-Torrent, Mónica López-Guerra, Laia Rosich, et al.Nature Communications|January 10, 2017
Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosomeCara Lunn Shirai, Brian S White, Manorama Tripathi, et al.Nature|September 3, 2015
The spliceosome is a therapeutic vulnerability in MYC-driven cancerTiffany Y-T Hsu, Lukas M Simon, Nicholas J Neill, et al.Pageof 2