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Molecular Pharmacology|February 1, 2024
Discovery and Characterization of VU0542270, the First Selective Inhibitor of Vascular Kir6.1/SUR2B K<sub>ATP</sub> ChannelsKangjun Li, Samantha J McClenahan, Changho Han, et al.Journal of Medicinal Chemistry|February 23, 2013
Evaluation of difluoromethyl ketones as agonists of the γ-aminobutyric acid type B (GABAB) receptorChangho Han, Amy E Salyer, Eun Hoo Kim, et al.Bioorganic & Medicinal Chemistry Letters|October 13, 2022
Discovery of a potent M<sub>5</sub> antagonist with improved clearance profile. Part 2: Pyrrolidine amide-based antagonistsDouglas L Orsi, Andrew S Felts, Alice L Rodriguez, et al.Bioorganic & Medicinal Chemistry Letters|March 26, 2023
Synthesis and SAR of a novel Kir6.2/SUR1 channel opener scaffold identified by HTSCayden J Dodd, Keagan S Chronister, Upendra Rathnayake, et al.Bioorganic & Medicinal Chemistry Letters|September 16, 2022
Discovery of a potent M<sub>5</sub> antagonist with improved clearance profile. Part 1: Piperidine amide-based antagonistsRory A Capstick, David Whomble, Douglas L Orsi, et al.ACS Chemical Neuroscience|August 8, 2018
Discovery of Tricyclic Triazolo- and Imidazopyridine Lactams as M<sub>1</sub> Positive Allosteric ModulatorsJulie L Engers, Aaron M Bender, Jacob J Kalbfleisch, et al.Journal of Medicinal Chemistry|December 12, 2023
Structure-Based Discovery of Potent, Orally Bioavailable Benzoxazepinone-Based WD Repeat Domain 5 InhibitorsKevin B Teuscher, Jonathan J Mills, Jianhua Tian, et al.Molecular Pharmacology|March 5, 2022
VU6036720: The First Potent and Selective In Vitro Inhibitor of Heteromeric Kir4.1/5.1 Inward Rectifier Potassium ChannelsSamantha J McClenahan, Caitlin N Kent, Sujay V Kharade, et al.ACS Medicinal Chemistry Letters|July 16, 2025
Discovery of a Novel sp<sup>3</sup>‑Rich M<sub>1</sub> Positive Allosteric Modulators (PAMs) Chemotype via Scaffold HoppingJoseph D Bungard, Paul Spearing, Yu Nishio, et al.ACS Chemical Neuroscience|March 25, 2025
Application of Deuterium in an M<sub>1</sub> Positive Allosteric Modulator Back-Up Program: The Discovery of VU6045422Julie L Engers, Jinming Li, Changho Han, et al.Pageof 5