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ACS Medicinal Chemistry Letters|August 20, 2021
Discovery of VU6028418: A Highly Selective and Orally Bioavailable M<sub>4</sub> Muscarinic Acetylcholine Receptor AntagonistMatthew Spock, Trever R Carter, Katrina A Bollinger, et al.Bioorganic & Medicinal Chemistry Letters|April 27, 2017
Optimization of M<sub>4</sub> positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacologyBruce J Melancon, Michael R Wood, Meredith J Noetzel, et al.Journal of Medicinal Chemistry|August 6, 2024
Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M<sub>5</sub> Muscarinic Acetylcholine ReceptorJinming Li, Douglas L Orsi, Julie L Engers, et al.Journal of Medicinal Chemistry|November 15, 2019
Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein InteractionJonathan D Macdonald, Selena Chacón Simon, Changho Han, et al.ACS Medicinal Chemistry Letters|May 14, 2025
Discovery of Thieno[3,2-<i>b</i>]pyridine-5-carboxamide and 2,3-Difluorobenzamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5Katherine E Crocker, Scott H Henderson, Rory A Capstick, et al.Bioorganic & Medicinal Chemistry Letters|May 18, 2016
Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine coreMichael R Wood, Meredith J Noetzel, Julie L Engers, et al.Journal of Medicinal Chemistry|April 13, 2022
Development of <b>VU6019650</b>: A Potent, Highly Selective, and Systemically Active Orthosteric Antagonist of the M<sub>5</sub> Muscarinic Acetylcholine Receptor for the Treatment of Opioid Use DisorderAaron T Garrison, Douglas L Orsi, Rory A Capstick, et al.Journal of Medicinal Chemistry|December 21, 2019
Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic CoreJianhua Tian, Kevin B Teuscher, Erin R Aho, et al.ACS Chemical Neuroscience|December 11, 2024
Discovery of VU0467319: an M<sub>1</sub> Positive Allosteric Modulator Candidate That Advanced into Clinical TrialsMichael S Poslunsey, Michael R Wood, Changho Han, et al.Bioorganic & Medicinal Chemistry Letters|June 29, 2019
SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M<sub>4</sub> PAMsTrevor C Chopko, Changho Han, Alison R Gregro, et al.Pageof 5