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Research Square|November 19, 2025
Mutant MAPT Induces rDNA Transcriptional Hyperactivation and Nucleolar Stress in Cellular ModelsZaid Muhammad, Yan Gu, Suleiman H Kwairanga, et al.Brain Communications|January 23, 2023
The PSEN1 E280G mutation leads to increased amyloid-β43 production in induced pluripotent stem cell neurons and deposition in brain tissueNanet Willumsen, Charles Arber, Christopher Lovejoy, et al.Brain Communications|April 23, 2026
Unbiased data-driven analysis of five amyloid-beta peptides for biomarker investigations in familial Alzheimer's diseaseIsaac Llorente-Saguer, Rebecca Gabriele, Teisha Y Bradshaw, et al.Autophagy Reports|June 19, 2026
Glucose concentration of neuronal media formulations influences PINK1-dependent mitophagy in human iNeuronsBenjamin O'Callaghan, Daniela Melandri, Darija Soltic, et al.Plos One|September 2, 2017
iPSC-derived neuronal models of PANK2-associated neurodegeneration reveal mitochondrial dysfunction contributing to early diseaseCharles Arber, Plamena R Angelova, Sarah Wiethoff, et al.Development (Cambridge, England)|March 26, 2015
Activin A directs striatal projection neuron differentiation of human pluripotent stem cellsCharles Arber, Sophie V Precious, Serafí Cambray, et al.Cell Reports|January 13, 2021
Familial Alzheimer's Disease Mutations in PSEN1 Lead to Premature Human Stem Cell NeurogenesisCharles Arber, Christopher Lovejoy, Lachlan Harris, et al.Journal of Cellular and Molecular Medicine|December 24, 2021
Elevated 4R-tau in astrocytes from asymptomatic carriers of the MAPT 10+16 intronic mutationNúria Setó-Salvia, Noemi Esteras, Rohan de Silva, et al.Molecular Psychiatry|April 14, 2019
Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid betaCharles Arber, Jamie Toombs, Christopher Lovejoy, et al.Molecular Neurodegeneration|June 20, 2025
Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer's disease through disrupted regulated intramembrane proteolysisOliver J Ziff, Gustavo Morrone Parfitt, Sarah Jolly, et al.Pageof 4