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Analytical Biochemistry|December 24, 2014
Residence time and kinetic efficiency analysis of extracellular signal-regulated kinase 2 inhibitorsDarin Vanderpool, Charles E Grimshaw, J David Lawson, et al.Bioscience Reports|June 9, 2017
Time-dependent inhibition of PHD2Isabelle Tcholakov, Charles E Grimshaw, Lihong Shi, et al.SLAS Discovery : Advancing Life Sciences R & D|October 21, 2020
Biochemical and Cellular Profile of NIK Inhibitors with Long Residence TimesPetro Halkowycz, Charles E Grimshaw, Walter Keung, et al.Bioorganic & Medicinal Chemistry Letters|May 18, 2017
Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activatorsZacharia S Cheruvallath, Stephen L Gwaltney, Mark Sabat, et al.Plos One|June 22, 2016
Trelagliptin (SYR-472, Zafatek), Novel Once-Weekly Treatment for Type 2 Diabetes, Inhibits Dipeptidyl Peptidase-4 (DPP-4) via a Non-Covalent MechanismCharles E Grimshaw, Andy Jennings, Ruhi Kamran, et al.Bioorganic & Medicinal Chemistry Letters|April 16, 2010
Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamidesJerome C Bressi, Andy J Jennings, Robert Skene, et al.Bioorganic & Medicinal Chemistry Letters|July 16, 2013
Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-ribose)polymerase inhibitorsAnthony R Gangloff, Jason Brown, Ron de Jong, et al.Bioorganic & Medicinal Chemistry Letters|December 26, 2015
Fragment-based drug discovery of potent and selective MKK3/6 inhibitorsMark Adams, Toshitake Kobayashi, J David Lawson, et al.Bioorganic & Medicinal Chemistry Letters|November 15, 2016
Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK)Betty Lam, Yasuyoshi Arikawa, Joshua Cramlett, et al.Oncotarget|May 3, 2018
TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myelomaKazuhide Nakayama, Magdalena M Szewczyk, Carlo Dela Sena, et al.Pageof 2