Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Filters

Charles Eigenbrot

Showing results (71-80 of 102) with videos related to

Pageof 11
Sort By:
Journal of Medicinal Chemistry|February 20, 2018
Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical DevelopmentJames J Crawford, Adam R Johnson, Dinah L Misner, et al.
Bioorganic & Medicinal Chemistry Letters|December 3, 2014
Design, synthesis and structure-activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK)Giancarlo Trani, John J Barker, Steven M Bromidge, et al.
Journal of Medicinal Chemistry|March 29, 2021
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3<i>H</i>)-quinazolinone Aryl Urea pan-RAF Kinase InhibitorMalcolm P Huestis, Darlene Dela Cruz, Antonio G DiPasquale, et al.
Bioorganic & Medicinal Chemistry Letters|July 23, 2013
2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitorsMichael Siu, Richard Pastor, Wendy Liu, et al.
Science Translational Medicine|November 4, 2016
Resolving TYK2 locus genotype-to-phenotype differences in autoimmunityCalliope A Dendrou, Adrian Cortes, Lydia Shipman, et al.
Bioorganic & Medicinal Chemistry Letters|October 31, 2012
Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2Sharada Labadie, Peter S Dragovich, Kathy Barrett, et al.
Bioorganic & Medicinal Chemistry Letters|December 4, 2014
Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenaseSharada Labadie, Peter S Dragovich, Jinhua Chen, et al.
The Journal of Clinical Investigation|May 12, 2010
Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized miceHans D Brightbill, Surinder Jeet, Zhonghua Lin, et al.
Journal of Medicinal Chemistry|November 11, 2014
Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutationEmily J Hanan, Charles Eigenbrot, Marian C Bryan, et al.
Journal of Medicinal Chemistry|October 13, 2015
Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case StudyRobert Heald, Krista K Bowman, Marian C Bryan, et al.
Pageof 11

Showing results (71-80 of 102) with videos related to

Sort By:
Pageof 11
Journal of Medicinal Chemistry|February 20, 2018
Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical DevelopmentJames J Crawford, Adam R Johnson, Dinah L Misner, et al.
Bioorganic & Medicinal Chemistry Letters|December 3, 2014
Design, synthesis and structure-activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK)Giancarlo Trani, John J Barker, Steven M Bromidge, et al.
Journal of Medicinal Chemistry|March 29, 2021
Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3<i>H</i>)-quinazolinone Aryl Urea pan-RAF Kinase InhibitorMalcolm P Huestis, Darlene Dela Cruz, Antonio G DiPasquale, et al.
Bioorganic & Medicinal Chemistry Letters|July 23, 2013
2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitorsMichael Siu, Richard Pastor, Wendy Liu, et al.
Science Translational Medicine|November 4, 2016
Resolving TYK2 locus genotype-to-phenotype differences in autoimmunityCalliope A Dendrou, Adrian Cortes, Lydia Shipman, et al.
Bioorganic & Medicinal Chemistry Letters|October 31, 2012
Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2Sharada Labadie, Peter S Dragovich, Kathy Barrett, et al.
Bioorganic & Medicinal Chemistry Letters|December 4, 2014
Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenaseSharada Labadie, Peter S Dragovich, Jinhua Chen, et al.
The Journal of Clinical Investigation|May 12, 2010
Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized miceHans D Brightbill, Surinder Jeet, Zhonghua Lin, et al.
Journal of Medicinal Chemistry|November 11, 2014
Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutationEmily J Hanan, Charles Eigenbrot, Marian C Bryan, et al.
Journal of Medicinal Chemistry|October 13, 2015
Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case StudyRobert Heald, Krista K Bowman, Marian C Bryan, et al.
Pageof 11