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Nature Communications|November 23, 2021
Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosisYanxiang Meng, Katherine A Davies, Cheree Fitzgibbon, et al.Cell Death & Disease|April 2, 2022
The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKLAnnette V Jacobsen, Catia L Pierotti, Kym N Lowes, et al.Proceedings of the National Academy of Sciences of the United States of America|April 3, 2020
Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using MonobodiesEmma J Petrie, Richard W Birkinshaw, Akiko Koide, et al.Nature Communications|June 21, 2020
Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologuesKatherine A Davies, Cheree Fitzgibbon, Samuel N Young, et al.Nature Communications|October 26, 2023
Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerizationYanxiang Meng, Sarah E Garnish, Katherine A Davies, et al.Nature Communications|April 14, 2021
Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosisSarah E Garnish, Yanxiang Meng, Akiko Koide, et al.The Biochemical Journal|April 28, 2023
The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinaseCatia L Pierotti, Annette V Jacobsen, Christoph Grohmann, et al.Cell Reports|September 26, 2019
Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3Emma J Petrie, Jarrod J Sandow, Wil I L Lehmann, et al.ACS Chemical Biology|September 9, 2020
Potent Inhibition of Necroptosis by Simultaneously Targeting Multiple Effectors of the PathwayCatia L Pierotti, Maria C Tanzer, Annette V Jacobsen, et al.Nature Communications|June 21, 2020
MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosisAndre L Samson, Ying Zhang, Niall D Geoghegan, et al.Pageof 3