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Toxins|February 26, 2026
Indole-3-Acetic Acid as a Putative Selective AhR Modulator Counteracts Skatole-Induced Dual-Hit Toxicity in Colorectal Cancer CellsChihiro Takei, Hidehisa Shimizu
International Journal of Molecular Sciences|December 11, 2025
The Gut Microbial Metabolite Indole-3-Acetic Acid Reprograms Systemic Homeostasis and Ameliorates IBD-Associated Cachexia Independent of Food IntakeAyame Tomii, Chihiro Takei, Keisuke Yoshikiyo, et al.
Toxins|January 24, 2025
The Role of Indoxyl Sulfate in Exacerbating Colorectal Cancer During Chronic Kidney Disease Progression: Insights into the Akt/β-Catenin/c-Myc and AhR/c-Myc Pathways in HCT-116 Colorectal Cancer CellsYu Ichisaka, Chihiro Takei, Kazuma Naito, et al.
Bioscience, Biotechnology, and Biochemistry|May 5, 2023
Activation of the TLR4-JNK but not the TLR4-ERK pathway induced by indole-3-acetic acid exerts anti-proliferative effects on Caco-2 cellsAyame Tomii, Manami Higa, Kazuma Naito, et al.
Fujita Medical Journal|May 4, 2026
Fusobacterium nucleatum as a two-hit amplifier in colorectal cancer pathogenesis: intersection of local and systemic mechanisms via the gut-kidney axisHidehisa Shimizu
Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation|December 28, 2011
Indoxyl sulfate induces nephrovascular senescenceToshimitsu Niwa, Hidehisa Shimizu
Toxins|February 26, 2026
Indoxyl Sulfate in the Gut-Kidney Axis: Pathophysiology and Clinical Significance in CKD-Associated Colorectal CancerHidehisa Shimizu, Toshimitsu Niwa
Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation|December 28, 2011
AST-120 ameliorates epithelial-to-mesenchymal transition and interstitial fibrosis in the kidneys of chronic kidney disease ratsDilinaer Bolati, Hidehisa Shimizu, Toshimitsu Niwa
American Journal of Nephrology|February 1, 2013
Indoxyl sulfate enhances p53-TGF-β1-Smad3 pathway in proximal tubular cellsHidehisa Shimizu, Maimaiti Yisireyili, Fuyuhiko Nishijima, et al.
Journal of Xenobiotics|February 26, 2026
Indole-3-Acetic Acid and Skatole Exert Opposing Effects on MDR1 Proteostasis in Human Colonic Epithelial Cells: A Molecular Basis for the Gut Microbial Metabolic SwitchKazuma Naito, Ayame Tomii, Katsunori Ishii, et al.
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