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ACS Medicinal Chemistry Letters|March 19, 2020
Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo ActivityNaomi S Rajapaksa, Alberto Gobbi, Joy Drobnick, et al.Journal of Medicinal Chemistry|May 15, 2019
Development of Potent and Selective Pyrazolopyrimidine IRAK4 InhibitorsMarian C Bryan, Joy Drobnick, Alberto Gobbi, et al.Journal of Medicinal Chemistry|November 11, 2014
Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutationEmily J Hanan, Charles Eigenbrot, Marian C Bryan, et al.Journal of Medicinal Chemistry|October 13, 2015
Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case StudyRobert Heald, Krista K Bowman, Marian C Bryan, et al.Bioorganic & Medicinal Chemistry Letters|December 18, 2015
Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stabilityWendy B Young, James Barbosa, Peter Blomgren, et al.Journal of Medicinal Chemistry|August 27, 2016
Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor InhibitorBryan K Chan, Emily J Hanan, Krista K Bowman, et al.Nature Chemical Biology|November 30, 2010
Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritisJulie A Di Paolo, Tao Huang, Mercedesz Balazs, et al.ACS Medicinal Chemistry Letters|June 17, 2026
Optimization and In Vivo Characterization of a Series of Cbl‑b Inactive-State InhibitorsMichael J Lambrecht, Jun Liang, Peter Man-Un Ung, et al.Frontiers in Oncology|April 2, 2025
IGV-001 cellular immunotherapy for newly diagnosed glioblastoma: overcoming the logistic challengeEric T Wong, Deus Cielo, Konstantina Svokos, et al.ACS Medicinal Chemistry Letters|June 19, 2024
Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate BindingJun Liang, Michael J Lambrecht, Teresita L Arenzana, et al.Pageof 11