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Expert Opinion on Therapeutic Patents|November 24, 2015
Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934)Christoph Boss, Catherine RochExpert Opinion on Therapeutic Patents|June 21, 2017
Orexin research: patent news from 2016Christoph Boss, Catherine RochBioorganic & Medicinal Chemistry Letters|June 6, 2015
Recent trends in orexin research--2010 to 2015Christoph Boss, Catherine RochRSC Medicinal Chemistry|January 29, 2024
Pyrazole derivatives as selective orexin-2 receptor antagonists (2-SORA): synthesis, structure-activity-relationship, and sleep-promoting properties in ratsChristine Brotschi, Martin H Bolli, John Gatfield, et al.Chimia|August 12, 2020
20 Years of Medicinal Chemistry - Always Look at the Bright Side (of Life)Christoph BossExpert Opinion on Therapeutic Patents|November 20, 2014
Orexin receptor antagonists--a patent review (2010 to August 2014)Christoph BossChemmedchem|May 9, 2019
Oxadiazole Derivatives as Dual Orexin Receptor Antagonists: Synthesis, Structure-Activity Relationships, and Sleep-Promoting Properties in RatsChristine Brotschi, Catherine Roch, John Gatfield, et al.Chemmedchem|September 16, 2020
The Quest for the Best Dual Orexin Receptor Antagonist (Daridorexant) for the Treatment of Insomnia DisordersChristoph Boss, John Gatfield, Christine Brotschi, et al.Chemmedchem|January 17, 2020
From Oxadiazole to Triazole Analogues: Optimization toward a Dual Orexin Receptor Antagonist with Improved in vivo Efficacy in DogsChristine Brotschi, Martin H Bolli, John Gatfield, et al.The Journal of Pharmacology and Experimental Therapeutics|July 1, 2017
The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468Alexander Treiber, Ruben de Kanter, Catherine Roch, et al.Pageof 9