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Chemmedchem|April 17, 2013
Discovery and characterization of ACT-335827, an orally available, brain penetrant orexin receptor type 1 selective antagonistMichel A Steiner, John Gatfield, Catherine Brisbare-Roch, et al.
Chemmedchem|March 8, 2023
Design, Synthesis, and Optimization of Indole Acetic Acid Derivatives as Potent and Selective CRTH2 Receptor Antagonists: Discovery of ACT-774312Hamed Aissaoui, Martin Holdener, Carmela Gnerre, et al.
The Journal of Biological Chemistry|April 21, 2005
X-ray structure of plasmepsin II complexed with a potent achiral inhibitorLars Prade, Andrew F Jones, Christoph Boss, et al.
Bioorganic & Medicinal Chemistry Letters|October 11, 2008
N-Glycine-sulfonamides as potent dual orexin 1/orexin 2 receptor antagonistsHamed Aissaoui, Ralf Koberstein, Cornelia Zumbrunn, et al.
Chimia|October 27, 2017
The Screening Compound Collection: A Key Asset for Drug DiscoveryChristoph Boss, Julien Hazemann, Thierry Kimmerlin, et al.
RSC Medicinal Chemistry|January 29, 2024
Pyrazole derivatives as selective orexin-2 receptor antagonists (2-SORA): synthesis, structure-activity-relationship, and sleep-promoting properties in ratsChristine Brotschi, Martin H Bolli, John Gatfield, et al.
Chemmedchem|March 9, 2023
CYP3A4 Catalyzes the Rearrangement of the Dual Orexin Receptor Antagonist Daridorexant to 4-Hydroxypiperidinol MetabolitesAlexander Treiber, Hamed Aissaoui, Stéphane Delahaye, et al.
Chemmedchem|November 20, 2023
Design of Dual EP2/EP4 Antagonists through Scaffold Merging of Selective InhibitorsOlivier Corminboeuf, Stefan Diethelm, Cornelia Zumbrunn, et al.
Bioorganic & Medicinal Chemistry Letters|February 26, 2013
Synthesis, structure-activity relationship studies, and identification of novel 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as dual orexin receptor antagonists. Part 1Thierry Sifferlen, Ralf Koberstein, Emmanuelle Cottreel, et al.
Bioorganic & Medicinal Chemistry Letters|May 31, 2013
Structure-activity relationship studies and sleep-promoting activity of novel 1-chloro-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as dual orexin receptor antagonists. Part 2Thierry Sifferlen, Ralf Koberstein, Emmanuelle Cottreel, et al.
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