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Journal of Medicinal Chemistry|February 8, 2024
Discovery of Nivasorexant (ACT-539313): The First Selective Orexin-1 Receptor Antagonist (SO1RA) Investigated in Clinical TrialsJodi T Williams, Martin H Bolli, Christine Brotschi, et al.Current Drug Metabolism|February 8, 2019
Metabolism of the Dual Orexin Receptor Antagonist ACT-541468, Based on Microtracer/ Accelerator Mass SpectrometryClemens Muehlan, Hartmut Fischer, Dieter Zimmer, et al.Bioorganic & Medicinal Chemistry Letters|February 11, 2010
Novel pyrazolo-tetrahydropyridines as potent orexin receptor antagonistsThierry Sifferlen, Christoph Boss, Emmanuelle Cottreel, et al.Chemmedchem|May 9, 2019
Oxadiazole Derivatives as Dual Orexin Receptor Antagonists: Synthesis, Structure-Activity Relationships, and Sleep-Promoting Properties in RatsChristine Brotschi, Catherine Roch, John Gatfield, et al.Chemmedchem|September 16, 2020
The Quest for the Best Dual Orexin Receptor Antagonist (Daridorexant) for the Treatment of Insomnia DisordersChristoph Boss, John Gatfield, Christine Brotschi, et al.Chemmedchem|January 17, 2020
From Oxadiazole to Triazole Analogues: Optimization toward a Dual Orexin Receptor Antagonist with Improved in vivo Efficacy in DogsChristine Brotschi, Martin H Bolli, John Gatfield, et al.Journal of Medicinal Chemistry|September 26, 2025
Cellular Potency Optimization of Novel Heme-Binding Imidazo[5,1-<i>b</i>]thiazoles, Imidazo[1,5-<i>a</i>]pyridines and Pyrazines as Potent IDO1 Inhibitors Devoid of Cytochrome P450 InhibitionSylvaine Cren, Carina Lotz-Jenne, Thierry Kimmerlin, et al.The Journal of Pharmacology and Experimental Therapeutics|July 1, 2017
The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468Alexander Treiber, Ruben de Kanter, Catherine Roch, et al.Bioorganic & Medicinal Chemistry Letters|December 25, 2012
Novel in vivo active anti-malarials based on a hydroxy-ethyl-amine scaffoldClaire-Lise Ciana, Romain Siegrist, Hamed Aissaoui, et al.Bioorganic & Medicinal Chemistry Letters|September 27, 2006
Inhibitors of Plasmepsin II-potential antimalarial agentsOlivier Corminboeuf, Guillaume Dunet, Mehdi Hafsi, et al.Pageof 5