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Molecules (Basel, Switzerland)|January 8, 2023
Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca<sup>2+</sup> Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 ActivationRim Malek, Alexey Simakov, Audrey Davis, et al.
European Journal of Medicinal Chemistry|April 6, 2016
Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatmentJean-Pierre Jourdan, Marc Since, Laïla El Kihel, et al.
British Journal of Pharmacology|December 28, 2019
Donecopride, a Swiss army knife with potential against Alzheimer's diseaseChristophe Rochais, Cédric Lecoutey, Katia Hamidouche, et al.
Chemmedchem|March 26, 2017
Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease TreatmentJean-Pierre Jourdan, Marc Since, Laïla El Kihel, et al.
Communications Biology|February 1, 2025
Evidence from a mouse model supports repurposing an anti-asthmatic drug, bambuterol, against Alzheimer's disease by administration through an intranasal routeAnne-Claire Groo, Thomas Curel, Aurélie Malzert-Fréon, et al.
European Journal of Medicinal Chemistry|January 26, 2015
Indenopyrazole oxime ethers: synthesis and β1-adrenergic blocking activityTommaso Angelone, Anna Caruso, Christophe Rochais, et al.
Molecules (Basel, Switzerland)|August 3, 2019
Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer's DiseaseFrançois-Xavier Toublet, Cédric Lecoutey, Julien Lalut, et al.
European Journal of Medicinal Chemistry|December 14, 2020
Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT<sub>6</sub> receptor antagonist with therapeutic interest in Alzheimer's diseaseFrançois-Xavier Toublet, Julien Lalut, Bérénice Hatat, et al.
RSC Medicinal Chemistry|July 8, 2026
Combining β<sub>2</sub>-AR agonism with butyrylcholinesterase inhibition, a synergistic neuroprotective action against Alzheimer's diseaseAlice Wang, Thomas Curel, Sylvie Claeysen, et al.
ACS Chemical Neuroscience|April 13, 2026
Rational Design and Evaluation of Rivastigmine-Based Pleiotropic Prodrugs for the Treatment of Alzheimer's DiseaseValentin Travers-Lesage, Marc Since, Alice Wang, et al.
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