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Journal of Medicinal Chemistry|September 18, 2015
Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel SynthesisWilliam D Shipe, Steven S Sharik, James C Barrow, et al.Bioorganic & Medicinal Chemistry Letters|March 9, 2010
Design and synthesis of conformationally constrained N,N-disubstituted 1,4-diazepanes as potent orexin receptor antagonistsPaul J Coleman, John D Schreier, Georgia B McGaughey, et al.Molecular Cancer Research : MCR|March 17, 2018
D-2-Hydroxyglutarate Is Necessary and Sufficient for Isocitrate Dehydrogenase 1 Mutant-Induced MIR148A Promoter MethylationTie Li, Christopher D Cox, Byram H Ozer, et al.Bioorganic & Medicinal Chemistry Letters|April 6, 2005
Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSPChristopher D Cox, Michael J Breslin, Brenda J Mariano, et al.Diabetes|October 9, 2013
Genetic deletion and pharmacological inhibition of phosphodiesterase 10A protects mice from diet-induced obesity and insulin resistanceAndrea R Nawrocki, Carlos G Rodriguez, Dawn M Toolan, et al.Journal of Neurogenetics|April 9, 2011
Promotion of sleep by suvorexant-a novel dual orexin receptor antagonistChristopher J Winrow, Anthony L Gotter, Christopher D Cox, et al.Neuropharmacology|July 4, 2012
The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkeySean M Smith, Jason M Uslaner, Christopher D Cox, et al.Bioorganic & Medicinal Chemistry Letters|August 16, 2012
Discovery of tetrahydropyridopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophreniaIzzat T Raheem, Michael J Breslin, Christine Fandozzi, et al.Journal of Neuro-Oncology|March 7, 2019
SPINT2 is hypermethylated in both IDH1 mutated and wild-type glioblastomas, and exerts tumor suppression via reduction of c-Met activationFei Liu, Christopher D Cox, Reshmi Chowdhury, et al.Neuropharmacology|October 25, 2011
Pharmacological characterization of MK-6096 - a dual orexin receptor antagonist for insomniaChristopher J Winrow, Anthony L Gotter, Christopher D Cox, et al.Pageof 4