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Bioorganic & Medicinal Chemistry Letters|June 17, 2015
Discovery of [¹¹C]MK-8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitorsChristopher D Cox, Eric D Hostetler, Broc A Flores, et al.Bioorganic & Medicinal Chemistry Letters|July 9, 2010
Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the ratPaul J Coleman, John D Schreier, Anthony J Roecker, et al.ACS Medicinal Chemistry Letters|April 15, 2021
Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor InteractionDouglas C Beshore, Gregory C Adam, Richard J O Barnard, et al.Bioorganic & Medicinal Chemistry Letters|March 31, 2007
Kinesin spindle protein (KSP) inhibitors. Part V: discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by beta-fluorination to overcome cellular efflux by P-glycoproteinChristopher D Cox, Michael J Breslin, David B Whitman, et al.Journal of Medicinal Chemistry|January 10, 2023
Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of SchizophreniaMark E Layton, Jeffrey C Kern, Timothy J Hartingh, et al.Bioorganic & Medicinal Chemistry Letters|November 9, 2017
The identification of a novel lead class for phosphodiesterase 2 inhibition by fragment-based drug designAshley B Forster, Pravien Abeywickrema, Jaime Bunda, et al.Neuro-Oncology Advances|March 3, 2020
Targeted next-generation sequencing of 565 neuro-oncology patients at UCLA: A single-institution experienceMatthew S Ji, Blaine S C Eldred, Regina Liu, et al.Bioorganic & Medicinal Chemistry Letters|November 26, 2015
Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophreniaIzzat T Raheem, John D Schreier, Joy Fuerst, et al.Bioorganic & Medicinal Chemistry Letters|January 12, 2015
Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexantIzzat T Raheem, Michael J Breslin, Joseph Bruno, et al.Molecular Imaging and Biology|November 25, 2015
Preclinical Characterization of the Phosphodiesterase 10A PET Tracer [(11)C]MK-8193Eric D Hostetler, Hong Fan, Aniket D Joshi, et al.Pageof 4