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ACS Medicinal Chemistry Letters|January 25, 2021

Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic ScreenMarina Bukhtiyarova, Erica M Cook, Paula J Hancock, et al.

Bioorganic & Medicinal Chemistry Letters|April 11, 2006

Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSPChristopher D Cox, Maricel Torrent, Michael J Breslin, et al.

Chemmedchem|May 7, 2009

Discovery of a potent, CNS-penetrant orexin receptor antagonist based on an n,n-disubstituted-1,4-diazepane scaffold that promotes sleep in ratsDavid B Whitman, Christopher D Cox, Michael J Breslin, et al.

Bioorganic & Medicinal Chemistry Letters|September 1, 2007

Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSPPaul J Coleman, John D Schreier, Christopher D Cox, et al.

Chemmedchem|December 31, 2013

Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomniaAnthony J Roecker, Swati P Mercer, John D Schreier, et al.

Journal of Medicinal Chemistry|June 27, 2008

Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancerChristopher D Cox, Paul J Coleman, Michael J Breslin, et al.

Chemmedchem|February 7, 2012

Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting propertiesPaul J Coleman, John D Schreier, Christopher D Cox, et al.

Bioorganic & Medicinal Chemistry Letters|September 25, 2014

Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomniaAnthony J Roecker, Thomas S Reger, M Christa Mattern, et al.

Journal of Medicinal Chemistry|June 23, 2010

Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomniaChristopher D Cox, Michael J Breslin, David B Whitman, et al.

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Showing results (31-40 of 39) with videos related to

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You have reached the last page of results.This site can display upto 39 results.

ACS Medicinal Chemistry Letters|January 25, 2021

Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic ScreenMarina Bukhtiyarova, Erica M Cook, Paula J Hancock, et al.

Bioorganic & Medicinal Chemistry Letters|April 11, 2006

Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSPChristopher D Cox, Maricel Torrent, Michael J Breslin, et al.

Chemmedchem|May 7, 2009

Discovery of a potent, CNS-penetrant orexin receptor antagonist based on an n,n-disubstituted-1,4-diazepane scaffold that promotes sleep in ratsDavid B Whitman, Christopher D Cox, Michael J Breslin, et al.

Bioorganic & Medicinal Chemistry Letters|September 1, 2007

Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSPPaul J Coleman, John D Schreier, Christopher D Cox, et al.

Chemmedchem|December 31, 2013

Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomniaAnthony J Roecker, Swati P Mercer, John D Schreier, et al.

Journal of Medicinal Chemistry|June 27, 2008

Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancerChristopher D Cox, Paul J Coleman, Michael J Breslin, et al.

Chemmedchem|February 7, 2012

Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting propertiesPaul J Coleman, John D Schreier, Christopher D Cox, et al.

Bioorganic & Medicinal Chemistry Letters|September 25, 2014

Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomniaAnthony J Roecker, Thomas S Reger, M Christa Mattern, et al.

Journal of Medicinal Chemistry|June 23, 2010

Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomniaChristopher D Cox, Michael J Breslin, David B Whitman, et al.

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