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Journal of Medicinal Chemistry
|
December 21, 2016
Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality
Christopher R Butler, Kevin Ogilvie, Luis Martinez-Alsina, et al.
ACS Medicinal Chemistry Letters
|
February 20, 2018
Late-Stage Microsomal Oxidation Reduces Drug-Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189
Antonia F Stepan, Tuan P Tran, Christopher J Helal, et al.
Journal of Medicinal Chemistry
|
June 10, 2011
Use of structure-based design to discover a potent, selective, in vivo active phosphodiesterase 10A inhibitor lead series for the treatment of schizophrenia
Christopher J Helal, Zhijun Kang, Xinjun Hou, et al.
Journal of Medicinal Chemistry
|
September 29, 2017
The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging
Lei Zhang, Laigao Chen, Elizabeth M Beck, et al.
Journal of Medicinal Chemistry
|
October 3, 2012
Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors
Michelle M Claffey, Christopher J Helal, Patrick R Verhoest, et al.
Cell Chemical Biology
|
September 30, 2020
Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoE
Uthpala Seneviratne, Zhen Huang, Christopher W Am Ende, et al.
Medchemcomm
|
August 16, 2018
Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy
Martin Pettersson, Douglas S Johnson, Danica A Rankic, et al.
Journal of Medicinal Chemistry
|
February 20, 2015
Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug design
Christopher R Butler, Michael A Brodney, Elizabeth M Beck, et al.
Journal of Medicinal Chemistry
|
March 3, 2018
Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation
Laura A McAllister, Christopher R Butler, Scot Mente, et al.
The Journal of Pharmacology and Experimental Therapeutics
|
February 14, 2012
Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo
Robin J Kleiman, Douglas S Chapin, Curt Christoffersen, et al.
Page
of 4
Search research articles
Search
Showing results (21-30 of 36) with videos related to
Sort By:
Page
of 4
Journal of Medicinal Chemistry
|
December 21, 2016
Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality
Christopher R Butler, Kevin Ogilvie, Luis Martinez-Alsina, et al.
ACS Medicinal Chemistry Letters
|
February 20, 2018
Late-Stage Microsomal Oxidation Reduces Drug-Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189
Antonia F Stepan, Tuan P Tran, Christopher J Helal, et al.
Journal of Medicinal Chemistry
|
June 10, 2011
Use of structure-based design to discover a potent, selective, in vivo active phosphodiesterase 10A inhibitor lead series for the treatment of schizophrenia
Christopher J Helal, Zhijun Kang, Xinjun Hou, et al.
Journal of Medicinal Chemistry
|
September 29, 2017
The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging
Lei Zhang, Laigao Chen, Elizabeth M Beck, et al.
Journal of Medicinal Chemistry
|
October 3, 2012
Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors
Michelle M Claffey, Christopher J Helal, Patrick R Verhoest, et al.
Cell Chemical Biology
|
September 30, 2020
Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoE
Uthpala Seneviratne, Zhen Huang, Christopher W Am Ende, et al.
Medchemcomm
|
August 16, 2018
Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy
Martin Pettersson, Douglas S Johnson, Danica A Rankic, et al.
Journal of Medicinal Chemistry
|
February 20, 2015
Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug design
Christopher R Butler, Michael A Brodney, Elizabeth M Beck, et al.
Journal of Medicinal Chemistry
|
March 3, 2018
Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation
Laura A McAllister, Christopher R Butler, Scot Mente, et al.
The Journal of Pharmacology and Experimental Therapeutics
|
February 14, 2012
Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo
Robin J Kleiman, Douglas S Chapin, Curt Christoffersen, et al.
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of 4