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The Journal of Pharmacology and Experimental Therapeutics|August 1, 2013
Positive allosteric modulation of AMPA receptors from efficacy to toxicity: the interspecies exposure-response continuum of the novel potentiator PF-4778574Christopher L Shaffer, Raymond S Hurst, Renato J Scialis, et al.Chemical Research in Toxicology|October 16, 2007
A rational chemical intervention strategy to circumvent bioactivation liabilities associated with a nonpeptidyl thrombopoietin receptor agonist containing a 2-amino-4-arylthiazole motifAmit S Kalgutkar, James Driscoll, Sabrina X Zhao, et al.Journal of Medicinal Chemistry|November 13, 2013
Discovery and characterization of a novel dihydroisoxazole class of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiatorsNandini C Patel, Jacob Schwarz, Xinjun J Hou, et al.Journal of Medicinal Chemistry|March 3, 2018
Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of NeuroinflammationLaura A McAllister, Christopher R Butler, Scot Mente, et al.Journal of Medicinal Chemistry|April 24, 2015
The discovery and characterization of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiator N-{(3S,4S)-4-[4-(5-cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242)Christopher L Shaffer, Nandini C Patel, Jacob Schwarz, et al.Journal of Medicinal Chemistry|January 8, 2014
Discovery and preclinical characterization of 1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulatorLei Zhang, Gayatri Balan, Gabriela Barreiro, et al.Journal of Medicinal Chemistry|August 18, 2017
Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman PrimatesAntonia F Stepan, Michelle M Claffey, Matthew R Reese, et al.Pageof 5