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Journal of Medicinal Chemistry|April 24, 2020
Facts, Patterns, and Principles in Drug Discovery: Appraising the Rule of 5 with Measured Physicochemical DataChristopher P Tinworth, Robert J YoungChemistry (Weinheim an Der Bergstrasse, Germany)|September 23, 2020
Computational Mapping of Dirhodium(II) CatalystsAdam I Green, Christopher P Tinworth, Stuart Warriner, et al.Chemistry (Weinheim an Der Bergstrasse, Germany)|May 28, 2020
Activity-Directed Synthesis of Inhibitors of the p53/hDM2 Protein-Protein InteractionAdam I Green, Fruzsina Hobor, Christopher P Tinworth, et al.ACS Chemical Biology|February 27, 2019
PROTAC-Mediated Degradation of Bruton's Tyrosine Kinase Is Inhibited by Covalent BindingChristopher P Tinworth, Hannah Lithgow, Lars Dittus, et al.ACS Chemical Biology|July 23, 2020
Structural Insights into PROTAC-Mediated Degradation of Bcl-xLChun-Wa Chung, Han Dai, Esther Fernandez, et al.Chemical Communications (Cambridge, England)|September 6, 2022
Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)Qisi Zhang, Cyrille S Kounde, Milon Mondal, et al.Journal of Medicinal Chemistry|February 29, 2020
Targeting the Regulatory Site of ER Aminopeptidase 1 Leads to the Discovery of a Natural Product Modulator of Antigen PresentationJohn Liddle, Jonathan P Hutchinson, Semra Kitchen, et al.ACS Medicinal Chemistry Letters|December 18, 2024
Optimization of Potent and Selective Cyclohexyl Acid ERAP1 Inhibitors Using Structure- and Property-Based Drug DesignRoss P Hryczanek, Andrew S Hackett, Paul Rowland, et al.Journal of Medicinal Chemistry|June 22, 2026
Discovery of an Orally Available Potent ER Aminopeptidase 1 (ERAP1) Inhibitor That Enhances Antitumor Responses and Limits Inflammatory Autoimmunity In VivoChristopher P Tinworth, Justyna Wojno-Picon, Michael Adam, et al.Journal of Medicinal Chemistry|April 13, 2026
Automated Molecular Design in BRADSHAW, Applied to the Optimization of ERAP1 InhibitorsRobert P Law, Ian D Wall, Richard Lonsdale, et al.Pageof 1