Showing results (51-60 of 60) with videos related to
Sort By:
Pageof 6
You have reached the last page of results.This site can display upto 60 results.
Nature Communications|October 12, 2016
Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitorsAndrea M Zuhl, Charles E Nolan, Michael A Brodney, et al.Bioorganic & Medicinal Chemistry Letters|March 21, 2012
Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulatorsMartin Pettersson, Douglas S Johnson, Chakrapani Subramanyam, et al.Journal of Medicinal Chemistry|November 18, 2017
Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol LipaseChristopher R Butler, Elizabeth M Beck, Anthony Harris, et al.Journal of Medicinal Chemistry|January 17, 2014
Design, synthesis, and pharmacological evaluation of a novel series of pyridopyrazine-1,6-dione γ-secretase modulatorsMartin Pettersson, Douglas S Johnson, Chakrapani Subramanyam, et al.ACS Medicinal Chemistry Letters|May 26, 2015
Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic StabilityMartin Pettersson, Douglas S Johnson, John M Humphrey, et al.Cell Chemical Biology|September 30, 2020
Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoEUthpala Seneviratne, Zhen Huang, Christopher W Am Ende, et al.Medchemcomm|August 16, 2018
Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacyMartin Pettersson, Douglas S Johnson, Danica A Rankic, et al.Science (New York, N.Y.)|April 25, 2024
Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cellsFabian Offensperger, Gary Tin, Miquel Duran-Frigola, et al.Nature Structural & Molecular Biology|December 15, 2022
Structural basis of the acyl-transfer mechanism of human GPAT1Zachary Lee Johnson, Mark Ammirati, David Jonathan Wasilko, et al.Journal of Medicinal Chemistry|June 7, 2024
Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's DiseaseMartin Pettersson, Douglas S Johnson, John M Humphrey, et al.Pageof 6