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Claire M Steppan

Showing results (21-30 of 32) with videos related to

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Bioorganic & Medicinal Chemistry Letters|February 13, 2010
C-Aryl glycoside inhibitors of SGLT2: Exploration of sugar modifications including C-5 spirocyclizationRalph P Robinson, Vincent Mascitti, Carine M Boustany-Kari, et al.
Cell Chemical Biology|September 30, 2020
Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoEUthpala Seneviratne, Zhen Huang, Christopher W Am Ende, et al.
Science Advances|July 24, 2024
In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillanceYuao Zhu, Irina Yurgelonis, Stephen Noell, et al.
Journal of Medicinal Chemistry|October 15, 2020
Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19Robert L Hoffman, Robert S Kania, Mary A Brothers, et al.
Journal of Medicinal Chemistry|April 1, 2011
Discovery of a clinical candidate from the structurally unique dioxa-bicyclo[3.2.1]octane class of sodium-dependent glucose cotransporter 2 inhibitorsVincent Mascitti, Tristan S Maurer, Ralph P Robinson, et al.
Frontiers in Pharmacology|August 27, 2021
An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of TransportersVojtech Dvorak, Tabea Wiedmer, Alvaro Ingles-Prieto, et al.
Molecular Systems Biology|May 12, 2025
Metabolic mapping of the human solute carrier superfamilyTabea Wiedmer, Shao Thing Teoh, Eirini Christodoulaki, et al.
Nature Structural & Molecular Biology|December 15, 2022
Structural basis of the acyl-transfer mechanism of human GPAT1Zachary Lee Johnson, Mark Ammirati, David Jonathan Wasilko, et al.
Journal of Medicinal Chemistry|April 4, 2018
Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking HypopigmentationBrian T O'Neill, Elizabeth M Beck, Christopher R Butler, et al.
Science (New York, N.Y.)|November 2, 2021
An oral SARS-CoV-2 M<sup>pro</sup> inhibitor clinical candidate for the treatment of COVID-19Dafydd R Owen, Charlotte M N Allerton, Annaliesa S Anderson, et al.
Pageof 4

Showing results (21-30 of 32) with videos related to

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Pageof 4
Bioorganic & Medicinal Chemistry Letters|February 13, 2010
C-Aryl glycoside inhibitors of SGLT2: Exploration of sugar modifications including C-5 spirocyclizationRalph P Robinson, Vincent Mascitti, Carine M Boustany-Kari, et al.
Cell Chemical Biology|September 30, 2020
Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoEUthpala Seneviratne, Zhen Huang, Christopher W Am Ende, et al.
Science Advances|July 24, 2024
In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillanceYuao Zhu, Irina Yurgelonis, Stephen Noell, et al.
Journal of Medicinal Chemistry|October 15, 2020
Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19Robert L Hoffman, Robert S Kania, Mary A Brothers, et al.
Journal of Medicinal Chemistry|April 1, 2011
Discovery of a clinical candidate from the structurally unique dioxa-bicyclo[3.2.1]octane class of sodium-dependent glucose cotransporter 2 inhibitorsVincent Mascitti, Tristan S Maurer, Ralph P Robinson, et al.
Frontiers in Pharmacology|August 27, 2021
An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of TransportersVojtech Dvorak, Tabea Wiedmer, Alvaro Ingles-Prieto, et al.
Molecular Systems Biology|May 12, 2025
Metabolic mapping of the human solute carrier superfamilyTabea Wiedmer, Shao Thing Teoh, Eirini Christodoulaki, et al.
Nature Structural & Molecular Biology|December 15, 2022
Structural basis of the acyl-transfer mechanism of human GPAT1Zachary Lee Johnson, Mark Ammirati, David Jonathan Wasilko, et al.
Journal of Medicinal Chemistry|April 4, 2018
Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking HypopigmentationBrian T O'Neill, Elizabeth M Beck, Christopher R Butler, et al.
Science (New York, N.Y.)|November 2, 2021
An oral SARS-CoV-2 M<sup>pro</sup> inhibitor clinical candidate for the treatment of COVID-19Dafydd R Owen, Charlotte M N Allerton, Annaliesa S Anderson, et al.
Pageof 4