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The AAPS Journal|October 14, 2020
In Vitro to In Vivo Extrapolation of Metabolic Clearance for UGT Substrates Using Short-Term Suspension and Long-Term Co-cultured Human HepatocytesLuca Docci, Florian Klammers, Aynur Ekiciler, et al.Drug Metabolism and Disposition: the Biological Fate of Chemicals|April 23, 2024
Physiologically Based Pharmacokinetic Modeling to Predict the Impact of Liver Cirrhosis on Glucuronidation via UGT1A4 and UGT2B7/2B4-A Case Study with MidazolamAgustos C Ozbey, Janneke Keemink, Bjoern Wagner, et al.The AAPS Journal|January 5, 2021
Understanding Mechanisms of Food Effect and Developing Reliable PBPK Models Using a Middle-out ApproachXavier J H Pepin, James E Huckle, Ravindra V Alluri, et al.Journal of Clinical Pharmacology|September 11, 2019
Characterization of the Ontogeny of Hepatic UDP-Glucuronosyltransferase Enzymes Based on Glucuronidation Activity Measured in Human Liver MicrosomesJustine Badée, Nahong Qiu, Abby C Collier, et al.Drug Metabolism and Disposition: the Biological Fate of Chemicals|August 3, 2020
Application of the Extended Clearance Classification System (ECCS) in Drug Discovery and Development: Selection of Appropriate In Vitro Tools and Clearance PredictionKenichi Umehara, Carina Cantrill, Matthias Beat Wittwer, et al.Transplantation|December 17, 2008
Outcome of pancreas transplantation in recipients older than 50 years: a single-centre experienceElijah Ablorsu, Abbas Ghazanfar, Sanjay Mehra, et al.Pharmaceutical Research|February 23, 2012
Mass spectrometry-based quantification of CYP enzymes to establish in vitro/in vivo scaling factors for intestinal and hepatic metabolism in beagle dogAki T Heikkinen, Arno Friedlein, Jens Lamerz, et al.The AAPS Journal|March 20, 2019
Simulating the Impact of Elevated Levels of Interleukin-6 on the Pharmacokinetics of Various CYP450 Substrates in Patients with Neuromyelitis Optica or Neuromyelitis Optica Spectrum Disorders in Different Ethnic PopulationsKrishna K Machavaram, Chihiro Endo-Tsukude, Kimio Terao, et al.Journal of Pharmaceutical Sciences|May 8, 2020
Current State and Future Expectations of Translational Modeling Strategies to Support Drug Product Development, Manufacturing Changes and Controls: A Workshop Summary ReportXavier J H Pepin, Neil Parrott, Jennifer Dressman, et al.Journal of Clinical Pharmacology|July 28, 2018
Effect of Hepatic Impairment on the Pharmacokinetics of AlectinibPeter N Morcos, Yumi Cleary, Carolina Sturm-Pellanda, et al.Pageof 14