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Cancer Research|October 3, 2007
Glutathione transferase pi plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethaneKenneth J Ritchie, Colin J Henderson, Xiu Jun Wang, et al.
Toxicological Sciences : an Official Journal of the Society of Toxicology|April 21, 2010
Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivoJillian Ross, Simon M Plummer, Anja Rode, et al.
Archives of Toxicology|October 14, 2019
The pyrrolizidine alkaloid senecionine induces CYP-dependent destruction of sinusoidal endothelial cells and cholestasis in miceStefanie Hessel-Pras, Albert Braeuning, Georgia Guenther, et al.
The Journal of Nutrition|December 1, 2004
Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanatesGail K McWalter, Larry G Higgins, Lesley I McLellan, et al.
Toxicology Letters|July 5, 2012
Exposure to benzo[a]pyrene of Hepatic Cytochrome P450 Reductase Null (HRN) and P450 Reductase Conditional Null (RCN) mice: Detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and 32P-postlabellingVolker M Arlt, Miriam C Poirier, Sarah E Sykes, et al.
Biochemical and Biophysical Research Communications|August 13, 2015
Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of actionRumen V Kostov, Elena V Knatko, Lesley A McLaughlin, et al.
Molecular and Cellular Biology|August 15, 2003
Identification of novel roles of the cytochrome p450 system in early embryogenesis: effects on vasculogenesis and retinoic Acid homeostasisDiana M E Otto, Colin J Henderson, Dianne Carrie, et al.
Communications Biology|September 16, 2021
Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancerElena V Knatko, Cecilia Castro, Maureen Higgins, et al.
Toxicology and Applied Pharmacology|January 28, 2019
Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticineLindsay Reed, Radek Indra, Iveta Mrizova, et al.
British Journal of Cancer|March 22, 2017
Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancerA Kenneth MacLeod, Lourdes Acosta-Jimenez, Philip J Coates, et al.
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