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Proceedings of the National Academy of Sciences of the United States of America|June 29, 2021
Elimination of fibrin γ-chain cross-linking by FXIIIa increases pulmonary embolism arising from murine inferior vena cava thrombiCédric Duval, Adomas Baranauskas, Tímea Feller, et al.ACS Medicinal Chemistry Letters|November 20, 2020
A Chemical Probe for the Methyl Transferase PRMT5 with a Novel Binding ModeVineet Pande, Weimei Sun, Lijs Beke, et al.Haematologica|February 5, 2026
Fibrin-bound thrombin determines clot structure and blood thrombogenicity in normofibrinogenemia and dysfibrinogenemiaSiyu Sun, Mark Roest, Rolf T Urbanus, et al.Journal of Medicinal Chemistry|November 5, 2016
The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of PainSarah E Skerratt, Mark Andrews, Sharan K Bagal, et al.The Journal of Biological Chemistry|March 22, 2018
Probing the quality control mechanism of the Escherichia coli twin-arginine translocase with folding variants of a de novo-designed heme proteinGeorge A Sutherland, Katie J Grayson, Nathan B P Adams, et al.ACS Medicinal Chemistry Letters|March 21, 2019
Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1)Mark Bell, David Foley, Claire Naylor, et al.RSC Medicinal Chemistry|January 8, 2026
Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferaseIrene Georgiou, Colin Robinson, Sean N O'Byrne, et al.The Biochemical Journal|March 6, 2014
Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitorsSeungil Han, Robert M Czerwinski, Nicole L Caspers, et al.Molecules (Basel, Switzerland)|February 15, 2022
Synthesis, Structure-Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 ReplicationDorothée Bardiot, Laura Vangeel, Mohamed Koukni, et al.Bioorganic & Medicinal Chemistry Letters|April 15, 2019
Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signalingMark Zak, Emily J Hanan, Patrick Lupardus, et al.Pageof 17