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Journal of Medicinal Chemistry|February 2, 2021
Design and Characterization of a Pyridone-Containing EZH2 Inhibitor Phosphate ProdrugPei-Pei Kung, Connie Fan, Hovhannes J Gukasyan, et al.Journal of Medicinal Chemistry|August 12, 2016
Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) InhibitorsPei-Pei Kung, Eugene Rui, Simon Bergqvist, et al.Journal of Medicinal Chemistry|December 7, 2017
Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497)Pei-Pei Kung, Patrick Bingham, Alexei Brooun, et al.Pageof 1