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Current Opinion in Pharmacology|May 20, 2014
Biased ligands: pathway validation for novel GPCR therapeuticsDavid H Rominger, Conrad L Cowan, William Gowen-MacDonald, et al.Journal of Clinical Pharmacology|July 2, 2013
First clinical experience with TRV027: pharmacokinetics and pharmacodynamics in healthy volunteersDavid G Soergel, Ruth Ann Subach, Conrad L Cowan, et al.Circulation|January 21, 2017
Long-Term Biased β-Arrestin Signaling Improves Cardiac Structure and Function in Dilated CardiomyopathyDavid M Ryba, Jieli Li, Conrad L Cowan, et al.Journal of Biomolecular Screening|August 12, 2005
Quantitative cell-based high-content screening for vasopressin receptor agonists using transfluor technologyRichik N Ghosh, Richard DeBiasio, Christine C Hudson, et al.Journal of Clinical Pharmacology|October 15, 2013
First clinical experience with TRV130: pharmacokinetics and pharmacodynamics in healthy volunteersDavid G Soergel, Ruth Ann Subach, Brian Sadler, et al.The Journal of Pharmacology and Experimental Therapeutics|May 24, 2017
TRV0109101, a G Protein-Biased Agonist of the µ-Opioid Receptor, Does Not Promote Opioid-Induced Mechanical Allodynia following Chronic AdministrationMichael Koblish, Richard Carr, Edward R Siuda, et al.Cardiovascular Research|June 6, 2015
Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy modelMadhusudhan Tarigopula, Robert T Davis, Paul T Mungai, et al.The Journal of Biological Chemistry|February 24, 2006
Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activationDiane Gesty-Palmer, Minyong Chen, Eric Reiter, et al.Journal of Medicinal Chemistry|September 26, 2013
Structure-activity relationships and discovery of a G protein biased μ opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe painXiao-Tao Chen, Philip Pitis, Guodong Liu, et al.The Journal of Pharmacology and Experimental Therapeutics|January 10, 2013
A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphineScott M DeWire, Dennis S Yamashita, David H Rominger, et al.Pageof 1