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Molecular Pharmacology|June 14, 2018
Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992Sujay V Kharade, Haruto Kurata, Aaron M Bender, et al.Bioorganic & Medicinal Chemistry Letters|May 2, 2016
Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacyRocco D Gogliotti, Darren W Engers, Pedro M Garcia-Barrantes, et al.Bioorganic & Medicinal Chemistry Letters|June 29, 2012
Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptorJames M Salovich, Paige N Vinson, Douglas J Sheffler, et al.Science Translational Medicine|August 18, 2017
mGlu<sub>7</sub> potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndromeRocco G Gogliotti, Rebecca K Senter, Nicole M Fisher, et al.The Journal of Biological Chemistry|July 29, 2011
Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channelsMelissa Miller, Jie Shi, Yingmin Zhu, et al.Bioorganic & Medicinal Chemistry Letters|July 1, 2018
Discovery and characterization of N-(1,3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine scaffold as mGlu<sub>4</sub> positive allosteric modulators that mitigate CYP1A2 induction liabilityDarren W Engers, Sean R Bollinger, Julie L Engers, et al.The Journal of Pharmacology and Experimental Therapeutics|November 18, 2011
The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's diseaseCarrie K Jones, Michael Bubser, Analisa D Thompson, et al.Bioorganic & Medicinal Chemistry Letters|November 27, 2012
Discovery of a selective M₄ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophreniaUyen Le, Bruce J Melancon, Thomas M Bridges, et al.Journal of Medicinal Chemistry|October 5, 2011
Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkinsonian animal modelCarrie K Jones, Darren W Engers, Analisa D Thompson, et al.The Journal of Biological Chemistry|October 4, 2012
Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmiasFranck Potet, Amanda N Lorinc, Sebastien Chaigne, et al.Pageof 13