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Science (New York, N.Y.)|December 9, 2017
A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal modelsYiming Zhou, Philip Castonguay, Eriene-Heidi Sidhom, et al.
ACS Chemical Neuroscience|April 15, 2016
Discovery, Synthesis, and Preclinical Characterization of N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4)Darren W Engers, Anna L Blobaum, Rocco D Gogliotti, et al.
ACS Medicinal Chemistry Letters|March 21, 2019
Discovery of VU2957 (Valiglurax): An mGlu<sub>4</sub> Positive Allosteric Modulator Evaluated as a Preclinical Candidate for the Treatment of Parkinson's DiseaseJoseph D Panarese, Darren W Engers, Yong-Jin Wu, et al.
ACS Chemical Neuroscience|September 17, 2014
Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7Nidhi Jalan-Sakrikar, Julie R Field, Rebecca Klar, et al.
Bioorganic & Medicinal Chemistry Letters|December 4, 2018
The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu<sub>4</sub> PAM development candidateJoseph D Panarese, Darren W Engers, Yong-Jin Wu, et al.
ACS Chemical Neuroscience|February 28, 2012
The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's DiseaseZixiu Xiang, Analisa D Thompson, John T Brogan, et al.
Bioorganic & Medicinal Chemistry Letters|May 18, 2016
Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine coreMichael R Wood, Meredith J Noetzel, Julie L Engers, et al.
ACS Chemical Neuroscience|December 11, 2024
Discovery of VU0467319: an M<sub>1</sub> Positive Allosteric Modulator Candidate That Advanced into Clinical TrialsMichael S Poslunsey, Michael R Wood, Changho Han, et al.
Cell|June 6, 2015
Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule ProbesStuart L Schreiber, Joanne D Kotz, Min Li, et al.
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