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Bioorganic & Medicinal Chemistry Letters|November 7, 2002
Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M(2) muscarinic receptor antagonists via benzamide modificationCraig D Boyle, Susan F Vice, Jennifer Campion, et al.ACS Medicinal Chemistry Letters|June 6, 2014
Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of DyslipidemiaAnandan Palani, Ashwin U Rao, Xiao Chen, et al.Bioorganic & Medicinal Chemistry Letters|April 20, 2005
Optimization of purine based PDE1/PDE5 inhibitors to a potent and selective PDE5 inhibitor for the treatment of male EDCraig D Boyle, Ruo Xu, Theodros Asberom, et al.ACS Medicinal Chemistry Letters|July 24, 2018
Discovery of MK-8318, a Potent and Selective CRTh2 Receptor Antagonist for the Treatment of AsthmaXianhai Huang, Jason Brubaker, Wei Zhou, et al.Journal of Medicinal Chemistry|June 26, 2024
Discovery of MK-1084: An Orally Bioavailable and Low-Dose KRASG12C InhibitorXiaoshen Ma, David L Sloman, Ruchia Duggal, et al.Journal of Medicinal Chemistry|April 9, 2026
From KRASG12D to Pan-KRAS Inhibitors─A Journey Enabled by Synthetic Innovation and Structure-Based Drug DesignXiaoshen Ma, David L Sloman, Timothy J Henderson, et al.Journal of Medicinal Chemistry|November 22, 2011
Cyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious γ-secretase modulators in vivoZhong-Yue Sun, Theodros Asberom, Thomas Bara, et al.Journal of Medicinal Chemistry|December 21, 2021
Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Nav1.7 for the Treatment of PainGregory L Adams, Parul S Pall, Steven M Grauer, et al.Pageof 7