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Nature Cell Biology|October 17, 2017
EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylationBeatrice Rondinelli, Ewa Gogola, Hatice Yücel, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|July 21, 2021
Opportunities for Utilization of DNA Repair Inhibitors in Homologous Recombination Repair-Deficient and Proficient Pancreatic AdenocarcinomaJames M Cleary, Brian M Wolpin, Stephanie K Dougan, et al.
Cancer Research|August 16, 2022
Targeting DNA Repair with Combined Inhibition of NHEJ and MMEJ Induces Synthetic Lethality in TP53-Mutant CancersJeffrey Patterson-Fortin, Arindam Bose, Wei-Chih Tsai, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|June 16, 2021
Phase 1 Combination Study of the CHK1 Inhibitor Prexasertib and the PARP Inhibitor Olaparib in High-grade Serous Ovarian Cancer and Other Solid TumorsKhanh T Do, Bose Kochupurakkal, Sarah Kelland, et al.
Science (New York, N.Y.)|June 18, 2002
Biallelic inactivation of BRCA2 in Fanconi anemiaNiall G Howlett, Toshiyasu Taniguchi, Susan Olson, et al.
Biorxiv : the Preprint Server for Biology|June 12, 2025
Lack of synergy between AR targeted therapies and PARP inhibitors in homologous recombination-proficient prostate cancerNicole A Traphagen, Esmé Wheeler, Rong Li, et al.
Journal of Gastrointestinal Oncology|January 24, 2022
Durable clinical benefit from PARP inhibition in a platinum-sensitive, BRCA2-mutated pancreatic cancer patient after earlier progression on placebo treatment on the POLO trial: a case reportDouglas Rubinson, Brian M Wolpin, Ilana S Warsofsky, et al.
Nature|February 3, 2015
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repairRaphael Ceccaldi, Jessica C Liu, Ravindra Amunugama, et al.
Proceedings of the National Academy of Sciences of the United States of America|November 15, 2024
PARG inhibitor sensitivity correlates with accumulation of single-stranded DNA gaps in preclinical models of ovarian cancerRamya Ravindranathan, Ozge Somuncu, Alexandre André B A da Costa, et al.
Cell Stem Cell|April 8, 2016
TGF-β Inhibition Rescues Hematopoietic Stem Cell Defects and Bone Marrow Failure in Fanconi AnemiaHaojian Zhang, David E Kozono, Kevin W O'Connor, et al.
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