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Bioorganic & Medicinal Chemistry Letters
|
September 29, 2015
Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase
Daniel W Kung, David A Griffith, William P Esler, et al.
Journal of Medicinal Chemistry
|
August 29, 2013
Spirolactam-based acetyl-CoA carboxylase inhibitors: toward improved metabolic stability of a chromanone lead structure
David A Griffith, Robert L Dow, Kim Huard, et al.
Journal of Medicinal Chemistry
|
December 14, 2011
Maximizing lipophilic efficiency: the use of Free-Wilson analysis in the design of inhibitors of acetyl-CoA carboxylase
Kevin D Freeman-Cook, Paul Amor, Scott Bader, et al.
Journal of Medicinal Chemistry
|
February 20, 2015
Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug design
Christopher R Butler, Michael A Brodney, Elizabeth M Beck, et al.
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|
June 30, 2022
First-in-Human Evaluation of <sup>18</sup>F-PF-06445974, a PET Radioligand That Preferentially Labels Phosphodiesterase-4B
Yuichi Wakabayashi, Per Stenkrona, Ryosuke Arakawa, et al.
Journal of Medicinal Chemistry
|
March 18, 2015
Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 inhibitors
Michael A Brodney, Elizabeth M Beck, Christopher R Butler, et al.
Journal of Medicinal Chemistry
|
May 31, 2018
Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS)
Jon H Come, Philip N Collier, James A Henderson, et al.
Journal of Medicinal Chemistry
|
April 4, 2018
Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation
Brian T O'Neill, Elizabeth M Beck, Christopher R Butler, et al.
Journal of Medicinal Chemistry
|
August 19, 2020
Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting
Kim Huard, Aaron C Smith, Gregg Cappon, et al.
Iucrj
|
October 9, 2014
Expression, purification and crystallization of CTB-MPR, a candidate mucosal vaccine component against HIV-1
Ho-Hsien Lee, Irene Cherni, HongQi Yu, et al.
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Search research articles
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Showing results (61-70 of 70) with videos related to
Sort By:
Page
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You have reached the last page of results.
This site can display upto 70 results.
Bioorganic & Medicinal Chemistry Letters
|
September 29, 2015
Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase
Daniel W Kung, David A Griffith, William P Esler, et al.
Journal of Medicinal Chemistry
|
August 29, 2013
Spirolactam-based acetyl-CoA carboxylase inhibitors: toward improved metabolic stability of a chromanone lead structure
David A Griffith, Robert L Dow, Kim Huard, et al.
Journal of Medicinal Chemistry
|
December 14, 2011
Maximizing lipophilic efficiency: the use of Free-Wilson analysis in the design of inhibitors of acetyl-CoA carboxylase
Kevin D Freeman-Cook, Paul Amor, Scott Bader, et al.
Journal of Medicinal Chemistry
|
February 20, 2015
Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug design
Christopher R Butler, Michael A Brodney, Elizabeth M Beck, et al.
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|
June 30, 2022
First-in-Human Evaluation of <sup>18</sup>F-PF-06445974, a PET Radioligand That Preferentially Labels Phosphodiesterase-4B
Yuichi Wakabayashi, Per Stenkrona, Ryosuke Arakawa, et al.
Journal of Medicinal Chemistry
|
March 18, 2015
Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 inhibitors
Michael A Brodney, Elizabeth M Beck, Christopher R Butler, et al.
Journal of Medicinal Chemistry
|
May 31, 2018
Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS)
Jon H Come, Philip N Collier, James A Henderson, et al.
Journal of Medicinal Chemistry
|
April 4, 2018
Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation
Brian T O'Neill, Elizabeth M Beck, Christopher R Butler, et al.
Journal of Medicinal Chemistry
|
August 19, 2020
Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting
Kim Huard, Aaron C Smith, Gregg Cappon, et al.
Iucrj
|
October 9, 2014
Expression, purification and crystallization of CTB-MPR, a candidate mucosal vaccine component against HIV-1
Ho-Hsien Lee, Irene Cherni, HongQi Yu, et al.
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