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Biochemistry|January 8, 2000
Mechanism of action and identification of Asp242 as the catalytic nucleophile of Vibrio furnisii N-acetyl-beta-D-glucosaminidase using 2-acetamido-2-deoxy-5-fluoro-alpha-L-idopyranosyl fluorideD J Vocadlo, C Mayer, S He, et al.
Nature|August 24, 2001
Catalysis by hen egg-white lysozyme proceeds via a covalent intermediateD J Vocadlo, G J Davies, R Laine, et al.
Biochemistry|May 1, 2001
Characterization of the Glu and Asp residues in the active site of human beta-hexosaminidase BY Hou, D J Vocadlo, A Leung, et al.
The Biochemical Journal|October 8, 1998
Identification of glu-277 as the catalytic nucleophile of Thermoanaerobacterium saccharolyticum beta-xylosidase using electrospray MSD J Vocadlo, L F MacKenzie, S He, et al.
Eneuro|October 10, 2023
Axonal Transport of Lysosomes Is Unaffected in Glucocerebrosidase-Inhibited iPSC-Derived Forebrain NeuronsA J Keefe, D R Gabrych, Y Zhu, et al.
The Journal of Biological Chemistry|August 28, 2001
Biochemical and structural assessment of the 1-N-azasugar GalNAc-isofagomine as a potent family 20 beta-N-acetylhexosaminidase inhibitorB L Mark, D J Vocadlo, D Zhao, et al.
The Journal of Biological Chemistry|January 2, 2001
Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidaseB L Mark, D J Vocadlo, S Knapp, et al.
Chemical Science|July 13, 2018
Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by human O-GlcNAcaseN Cekic, J E Heinonen, K A Stubbs, et al.
Organic & Biomolecular Chemistry|December 23, 2021
Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and C-alkylation leads to low micromolar HexAB and NagZ inhibitorsJ Bouquet, N Auberger, R Ashmus, et al.
Organic & Biomolecular Chemistry|May 18, 2017
Selective trihydroxylated azepane inhibitors of NagZ, a glycosidase involved in Pseudomonas aeruginosa resistance to β-lactam antibioticsJ Bouquet, D T King, G Vadlamani, et al.
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