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Methods in Enzymology|January 10, 2017
Enzymatic Assays for Studying Intramembrane ProteolysisD M Bolduc, D J Selkoe, M S WolfeAnnals of the New York Academy of Sciences|February 24, 2001
Toward the characterization and identification of gamma-secretases using transition-state analogue inhibitorsC L Moore, T S Diehl, D J Selkoe, et al.The Journal of Biological Chemistry|February 1, 2000
The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generationW T Kimberly, W Xia, T Rahmati, et al.Biochemistry|September 2, 1999
Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's diseaseM S Wolfe, J De Los Angeles, D D Miller, et al.Journal of Medicinal Chemistry|September 9, 2000
Difluoro ketone peptidomimetics suggest a large S1 pocket for Alzheimer's gamma-secretase: implications for inhibitor designC L Moore, D D Leatherwood, T S Diehl, et al.Nature|April 17, 1999
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activityM S Wolfe, W Xia, B L Ostaszewski, et al.Current Opinion in Neurobiology|February 19, 2000
Notch and presenilins in vertebrates and invertebrates: implications for neuronal development and degenerationD J SelkoeProceedings of the National Academy of Sciences of the United States of America|September 27, 2001
Presenilin, Notch, and the genesis and treatment of Alzheimer's diseaseD J SelkoeNeurobiology of Aging|November 1, 1986
Altered structural proteins in plaques and tangles: what do they tell us about the biology of Alzheimer's disease?D J SelkoeAnnals of the New York Academy of Sciences|February 24, 2001
Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-proteinD J SelkoePageof 23