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Bioorganic & Medicinal Chemistry Letters|January 15, 2013
Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitorsXiaocong M Ye, Andrei W Konradi, Minghua Sun, et al.
Bioorganic & Medicinal Chemistry Letters|July 17, 2013
Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitorsRaymond A Ng, Minghua Sun, Simeon Bowers, et al.
Bioorganic & Medicinal Chemistry Letters|July 17, 2010
Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: structure-activity relationship of P2' substituentsAnh P Truong, Gary D Probst, Jose Aquino, et al.
Bioorganic & Medicinal Chemistry Letters|March 20, 2009
Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitorPenglie Zhang, Wenrong Huang, Lingyan Wang, et al.
Bioorganic & Medicinal Chemistry Letters|August 8, 2009
Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitorsAnh P Truong, Danielle L Aubele, Gary D Probst, et al.
Bioorganic & Medicinal Chemistry Letters|November 30, 2010
Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegenerationGary D Probst, Simeon Bowers, Jennifer M Sealy, et al.
Bioorganic & Medicinal Chemistry Letters|September 14, 2010
Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal modelAnh P Truong, Gergley Tóth, Gary D Probst, et al.
Bioorganic & Medicinal Chemistry Letters|September 9, 2010
Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl regionGary D Probst, Simeon Bowers, Jennifer M Sealy, et al.
Bioorganic & Medicinal Chemistry Letters|August 5, 2011
Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegenerationSimeon Bowers, Anh P Truong, R Jeffrey Neitz, et al.
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