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Journal of Medicinal Chemistry|March 15, 2021
Discovery of an Orally Efficacious Positive Allosteric Modulator of the Glucagon-like Peptide-1 ReceptorFrancis S Willard, David B Wainscott, Aaron D Showalter, et al.Journal of Medicinal Chemistry|May 29, 1999
Tyrosine kinase inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(phenylamino)pyrido[d]pyrimidine acrylamides as irreversible inhibitors of the ATP binding site of the epidermal growth factor receptorJ B Smaill, B D Palmer, G W Rewcastle, et al.JCI Insight|July 31, 2020
Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonistFrancis S Willard, Jonathan D Douros, Maria Bn Gabe, et al.Journal of Medicinal Chemistry|July 18, 1997
Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitorsJ M Hamby, C J Connolly, M C Schroeder, et al.Journal of Medicinal Chemistry|October 23, 1998
Synthesis and tyrosine kinase inhibitory activity of a series of 2-amino-8H-pyrido[2,3-d]pyrimidines: identification of potent, selective platelet-derived growth factor receptor tyrosine kinase inhibitorsD H Boschelli, Z Wu, S R Klutchko, et al.Proceedings of the National Academy of Sciences of the United States of America|March 25, 2022
Structural determinants of dual incretin receptor agonism by tirzepatideBingfa Sun, Francis S Willard, Dan Feng, et al.The Journal of Clinical Investigation|June 3, 2004
Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitorsKyle W Sloop, Julia Xiao-Chun Cao, Angela M Siesky, et al.Science Translational Medicine|December 18, 2024
The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipronKyle W Sloop, Amy L Cox, David B Wainscott, et al.Journal of Medicinal Chemistry|June 1, 2001
Soluble 2-substituted aminopyrido[2,3-d]pyrimidin-7-yl ureas. Structure-activity relationships against selected tyrosine kinases and exploration of in vitro and in vivo anticancer activityM C Schroeder, J M Hamby, C J Connolly, et al.Journal of Medicinal Chemistry|August 14, 1998
2-Substituted aminopyrido[2,3-d]pyrimidin-7(8H)-ones. structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activityS R Klutchko, J M Hamby, D H Boschelli, et al.Pageof 15