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Nucleic Acids Research|September 29, 2025
Modified unlocked nucleic acid (MUNA) mitigates off-target effects of small interfering RNAsShohei Mori, Dhrubajyoti Datta, Lydia Perkins, et al.The Journal of Organic Chemistry|September 17, 2013
Identification and characterization of second-generation invader locked nucleic acids (LNAs) for mixed-sequence recognition of double-stranded DNASujay P Sau, Andreas S Madsen, Peter Podbevsek, et al.Journal of the American Chemical Society|August 3, 2022
Role of a "Magic" Methyl: 2'-Deoxy-2'-α-F-2'-β-<i>C</i>-methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5'-Phosphate Mimics and Mitigation of Off-Target EffectsDale C Guenther, Shohei Mori, Shigeo Matsuda, et al.Nucleic Acids Research|September 11, 2021
Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencingHartmut Jahns, Rohan Degaonkar, Peter Podbevsek, et al.Journal of the American Chemical Society|September 23, 2017
4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene SilencingElise Malek-Adamian, Dale C Guenther, Shigeo Matsuda, et al.Journal of the American Chemical Society|August 28, 2023
Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAsShigeo Matsuda, Saikat Bala, Jen-Yu Liao, et al.Nature Biotechnology|June 2, 2022
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugatesKirk M Brown, Jayaprakash K Nair, Maja M Janas, et al.Pageof 3