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Nature|February 16, 2026
De novo design of GPCR exoframe modulatorsShizhuo Cheng, Jia Guo, Yun-Li Zhou, et al.Bioorganic Chemistry|February 18, 2020
Natural protoberberine alkaloids, identified as potent selective LSD1 inhibitors, induce AML cell differentiationZhong-Rui Li, Feng-Zhi Suo, Yan-Jia Guo, et al.Molecular Cancer|March 17, 2022
LSD1 deletion decreases exosomal PD-L1 and restores T-cell response in gastric cancerDan-Dan Shen, Jing-Ru Pang, Ya-Ping Bi, et al.Science Advances|March 25, 2021
A tumor-suppressive circular RNA mediates uncanonical integrin degradation by the proteasome in liver cancerLiang Shi, Boqiang Liu, Dan-Dan Shen, et al.Molecular Cell|June 17, 2022
GPCRs steer G<sub>i</sub> and G<sub>s</sub> selectivity via TM5-TM6 switches as revealed by structures of serotonin receptorsSijie Huang, Peiyu Xu, Dan-Dan Shen, et al.Advanced Science (Weinheim, Baden-Wurttemberg, Germany)|April 22, 2024
Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRsQingya Shen, Xinyan Tang, Xin Wen, et al.Nature Chemical Biology|December 24, 2021
Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1Zhehua Shao, Qingya Shen, Bingpeng Yao, et al.Cell Research|August 26, 2021
Structural insights into ligand recognition and activation of the melanocortin-4 receptorHuibing Zhang, Li-Nan Chen, Dehua Yang, et al.Cell|March 1, 2024
Structure-based design of non-hypertrophic apelin receptor modulatorWei-Wei Wang, Su-Yu Ji, Wenjia Zhang, et al.Nature Communications|March 21, 2026
Functional and structural basis of a negative allostery within GABA<sub>B</sub> hetero-tetramersCangsong Shen, Hongyang Ding, Shenlan Zhang, et al.Pageof 8