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Topics in Current Chemistry
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June 8, 2011
Combining NMR and X-ray crystallography in fragment-based drug discovery: discovery of highly potent and selective BACE-1 inhibitors
Daniel F Wyss, Yu-Sen Wang, Hugh L Eaton, et al.
Journal of Medicinal Chemistry
|
April 30, 2004
Non-peptidic small-molecule inhibitors of the single-chain hepatitis C virus NS3 protease/NS4A cofactor complex discovered by structure-based NMR screening
Daniel F Wyss, Ashok Arasappan, Mary M Senior, et al.
Journal of Biomolecular Screening
|
March 31, 2016
NMR Binding and Functional Assays for Detecting Inhibitors of S. aureus MnaA
Yan Hou, Todd Mayhood, Payal Sheth, et al.
Nucleic Acids Research
|
July 24, 2023
Characterization of RNA driven structural changes in full length RIG-I leading to its agonism or antagonism
Justyna Sikorska, Yan Hou, Paul Chiurazzi, et al.
ACS Medicinal Chemistry Letters
|
June 6, 2014
Pyridine Carboxamides: Potent Palm Site Inhibitors of HCV NS5B Polymerase
Cliff C Cheng, Xiaohua Huang, Gerald W Shipps, et al.
ACS Medicinal Chemistry Letters
|
June 6, 2014
Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors
Xiaohua Huang, Gerald W Shipps, Cliff C Cheng, et al.
Journal of Medicinal Chemistry
|
January 2, 2010
Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors
Yu-Sen Wang, Corey Strickland, Johannes H Voigt, et al.
Journal of Medicinal Chemistry
|
January 2, 2010
Discovery of cyclic acylguanidines as highly potent and selective beta-site amyloid cleaving enzyme (BACE) inhibitors: Part I--inhibitor design and validation
Zhaoning Zhu, Zhong-Yue Sun, Yuanzan Ye, et al.
Nature Communications
|
January 3, 2026
WRN structural flexibility showcased through fragment-based lead discovery of inhibitors
Rachel L Palte, Mihir Mandal, Justyna Sikorska, et al.
Journal of Medicinal Chemistry
|
March 25, 2022
Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer
Wonsuk Chang, Michael D Altman, Charles A Lesburg, et al.
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Search research articles
Search
Showing results (21-30 of 32) with videos related to
Sort By:
Page
of 4
Topics in Current Chemistry
|
June 8, 2011
Combining NMR and X-ray crystallography in fragment-based drug discovery: discovery of highly potent and selective BACE-1 inhibitors
Daniel F Wyss, Yu-Sen Wang, Hugh L Eaton, et al.
Journal of Medicinal Chemistry
|
April 30, 2004
Non-peptidic small-molecule inhibitors of the single-chain hepatitis C virus NS3 protease/NS4A cofactor complex discovered by structure-based NMR screening
Daniel F Wyss, Ashok Arasappan, Mary M Senior, et al.
Journal of Biomolecular Screening
|
March 31, 2016
NMR Binding and Functional Assays for Detecting Inhibitors of S. aureus MnaA
Yan Hou, Todd Mayhood, Payal Sheth, et al.
Nucleic Acids Research
|
July 24, 2023
Characterization of RNA driven structural changes in full length RIG-I leading to its agonism or antagonism
Justyna Sikorska, Yan Hou, Paul Chiurazzi, et al.
ACS Medicinal Chemistry Letters
|
June 6, 2014
Pyridine Carboxamides: Potent Palm Site Inhibitors of HCV NS5B Polymerase
Cliff C Cheng, Xiaohua Huang, Gerald W Shipps, et al.
ACS Medicinal Chemistry Letters
|
June 6, 2014
Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors
Xiaohua Huang, Gerald W Shipps, Cliff C Cheng, et al.
Journal of Medicinal Chemistry
|
January 2, 2010
Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors
Yu-Sen Wang, Corey Strickland, Johannes H Voigt, et al.
Journal of Medicinal Chemistry
|
January 2, 2010
Discovery of cyclic acylguanidines as highly potent and selective beta-site amyloid cleaving enzyme (BACE) inhibitors: Part I--inhibitor design and validation
Zhaoning Zhu, Zhong-Yue Sun, Yuanzan Ye, et al.
Nature Communications
|
January 3, 2026
WRN structural flexibility showcased through fragment-based lead discovery of inhibitors
Rachel L Palte, Mihir Mandal, Justyna Sikorska, et al.
Journal of Medicinal Chemistry
|
March 25, 2022
Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer
Wonsuk Chang, Michael D Altman, Charles A Lesburg, et al.
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of 4