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Chemical Science|August 30, 2024
The backbone constitution drives passive permeability independent of side chains in depsipeptide and peptide macrocycles inspired by <i>ent</i>-verticilideMadelaine P Thorpe, Abigail N Smith, Daniel J Blackwell, et al.
Circulation Research|September 14, 2022
Impaired Dynamic Sarcoplasmic Reticulum Ca Buffering in Autosomal Dominant CPVT2Matthew J Wleklinski, Dmytro O Kryshtal, Kyungsoo Kim, et al.
Biochimica Et Biophysica Acta. Biomembranes|August 11, 2019
Intrinsically disordered HAX-1 regulates Ca<sup>2+</sup> cycling by interacting with lipid membranes and the phospholamban cytoplasmic regionErik K Larsen, Daniel K Weber, Songlin Wang, et al.
The Journal of Pharmacology and Experimental Therapeutics|March 9, 2023
In Vivo Pharmacokinetic and Pharmacodynamic Properties of the Antiarrhythmic Molecule <i>ent</i>-VerticilideDaniel J Blackwell, Abigail N Smith, Tri Do, et al.
Molecular Pharmacology|December 3, 2025
Introduction of a single carboxylic acid converts the cyclic oligomeric depsipeptide ent-verticilide from a ryanodine receptor 2 (RyR2) inhibitor to RyR2 activatorTri Q Do, Daniel J Blackwell, Abigail N Smith, et al.
ACS Medicinal Chemistry Letters|November 17, 2022
Structure-Activity Relationships for the <i>N</i>-Me- Versus <i>N</i>-H-Amide Modification to Macrocyclic <i>ent</i>-Verticilide AntiarrhythmicsAbigail N Smith, Madelaine P Thorpe, Daniel J Blackwell, et al.
Plos One|February 11, 2021
Assessment of dynamic cardiac repolarization and contractility in patients with hypertrophic cardiomyopathyAndrew E Radbill, Lucy Y Lei, Sachin Y Paranjape, et al.
Circulation Research|December 10, 2020
RYR2 Channel Inhibition Is the Principal Mechanism of Flecainide Action in CPVTDmytro O Kryshtal, Daniel J Blackwell, Christian L Egly, et al.
Proceedings of the National Academy of Sciences of the United States of America|February 23, 2019
Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmicSuzanne M Batiste, Daniel J Blackwell, Kyungsoo Kim, et al.
Heart Rhythm|April 21, 2019
Patient-independent human induced pluripotent stem cell model: A new tool for rapid determination of genetic variant pathogenicity in long QT syndromeNikhil V Chavali, Dmytro O Kryshtal, Shan S Parikh, et al.
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