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The AAPS Journal|April 25, 2025
Realistic Albumin Concentrations in Virtual Subjects Across A Spectrum of Renal Function to Account for Variability in Protein Binding Within PBPK ModelsYuming Hu, Daniel Scotcher
The AAPS Journal|December 15, 2021
PBPK Simulation-Based Evaluation of Ganciclovir Crystalluria Risk Factors: Effect of Renal Impairment, Old Age, and Low Fluid IntakeDaniel Scotcher, Aleksandra Galetin
European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences|April 2, 2016
Novel minimal physiologically-based model for the prediction of passive tubular reabsorption and renal excretion clearanceDaniel Scotcher, Christopher Jones, Amin Rostami-Hodjegan, et al.
CPT: Pharmacometrics & Systems Pharmacology|March 11, 2025
Genotype, Ethnicity, and Drug-Drug Interaction Modeling as Means of Verifying Transporter Biomarker PBPK Model: The Coproporphyrin-I StoryYuki Ujihira, Shawn Pei Feng Tan, Daniel Scotcher, et al.
The Journal of Pharmacology and Experimental Therapeutics|January 7, 2017
Delineating the Role of Various Factors in Renal Disposition of Digoxin through Application of Physiologically Based Kidney Model to Renal Impairment PopulationsDaniel Scotcher, Christopher R Jones, Aleksandra Galetin, et al.
The AAPS Journal|July 2, 2016
Key to Opening Kidney for In Vitro-In Vivo Extrapolation Entrance in Health and Disease: Part I: In Vitro Systems and Physiological DataDaniel Scotcher, Christopher Jones, Maria Posada, et al.
The AAPS Journal|August 11, 2016
Key to Opening Kidney for In Vitro-In Vivo Extrapolation Entrance in Health and Disease: Part II: Mechanistic Models and In Vitro-In Vivo ExtrapolationDaniel Scotcher, Christopher Jones, Maria Posada, et al.
Clinical Pharmacology and Therapeutics|May 15, 2022
Effect of Chronic Kidney Disease on the Renal Secretion via Organic Anion Transporters 1/3: Implications for Physiologically-Based Pharmacokinetic Modeling and Dose AdjustmentShawn Pei Feng Tan, Daniel Scotcher, Amin Rostami-Hodjegan, et al.
CPT: Pharmacometrics & Systems Pharmacology|October 13, 2020
Physiologically-Based Pharmacokinetic Modelling of Creatinine-Drug Interactions in the Chronic Kidney Disease PopulationHiroyuki Takita, Daniel Scotcher, Rajkumar Chinnadurai, et al.
The Journal of Pharmacology and Experimental Therapeutics|November 11, 2018
Towards Further Verification of Physiologically-Based Kidney Models: Predictability of the Effects of Urine-Flow and Urine-pH on Renal ClearanceTakanobu Matsuzaki, Daniel Scotcher, Adam S Darwich, et al.
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