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CPT: Pharmacometrics & Systems Pharmacology|March 4, 2025
Evaluation of Adefovir PBPK Model to Assess Biomarker-Informed OAT1 Drug-Drug Interaction and Effect of Chronic Kidney DiseaseShawn Pei Feng Tan, Huaying Wu, Amin Rostami-Hodjegan, et al.Drug Metabolism and Disposition: the Biological Fate of Chemicals|March 19, 2026
Overlooked aspects of scaling enzyme activity through abundance across tissues and individuals: Insights from k<sub>cat</sub> measurements in matched liver and intestinal samplesZubida M Al-Majdoub, Jill Barber, Amin Rostami-Hodjegan, et al.Clinical Pharmacology and Therapeutics|June 2, 2022
Coproporphyrin I as an Endogenous Biomarker to Detect Reduced OATP1B Activity and Shift in Elimination Route in Chronic Kidney DiseaseHiroyuki Takita, Daniel Scotcher, Xiaoyan Chu, et al.Clinical Pharmacology and Therapeutics|August 14, 2021
Quantitative Proteomic Map of Enzymes and Transporters in the Human Kidney: Stepping Closer to Mechanistic Kidney Models to Define Local KineticsZubida M Al-Majdoub, Daniel Scotcher, Brahim Achour, et al.Molecular Pharmaceutics|August 21, 2024
Albumin-Mediated Drug Uptake by Organic Anion Transporter 1/3 Is Real: Implications for the Prediction of Active Renal Secretion ClearanceShawn Pei Feng Tan, Annika Tillmann, Susan J Murby, et al.Journal of Pharmaceutical Sciences|February 28, 2024
Facing the Facts of Altered Plasma Protein Binding: Do Current Models Correctly Predict Changes in Fraction Unbound in Special Populations?Jokha Al-Qassabi, Shawn Pei Feng Tan, Patcharapan Phonboon, et al.Drug Metabolism and Disposition: the Biological Fate of Chemicals|March 9, 2017
Microsomal and Cytosolic Scaling Factors in Dog and Human Kidney Cortex and Application for In Vitro-In Vivo Extrapolation of Renal Metabolic ClearanceDaniel Scotcher, Sarah Billington, Jay Brown, et al.Clinical Pharmacology and Therapeutics|August 24, 2023
Development of 4-Pyridoxic Acid PBPK Model to Support Biomarker-Informed Evaluation of OAT1/3 Inhibition and Effect of Chronic Kidney DiseaseShawn Pei Feng Tan, Marie-Emilie Willemin, Jan Snoeys, et al.Drug Metabolism and Disposition: the Biological Fate of Chemicals|September 26, 2020
Scaling Factors for Clearance in Adult Liver CirrhosisEman El-Khateeb, Brahim Achour, Daniel Scotcher, et al.CPT: Pharmacometrics & Systems Pharmacology|May 16, 2020
Mechanistic Models as Framework for Understanding Biomarker Disposition: Prediction of Creatinine-Drug InteractionsDaniel Scotcher, Vikram Arya, Xinning Yang, et al.Pageof 4