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Bioorganic & Medicinal Chemistry
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May 17, 2018
Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition
Daren Fearon, Isaac M Westwood, Rob L M van Montfort, et al.
Organic Letters
|
October 20, 2022
Synthesis of a Thiazole Library via an Iridium-Catalyzed Sulfur Ylide Insertion Reaction
Storm Hassell-Hart, Elisa Speranzini, Sirihathai Srikwanjai, et al.
Chemmedchem
|
May 23, 2026
Fragment-Based Design of Targeted Covalent Inhibitors: The Scope and Limitation of Linking Approaches
Levente Kollár, Levente M Mihalovits, Dávid Bajusz, et al.
Biorxiv : the Preprint Server for Biology
|
October 3, 2025
How many crystal structures do you need to trust your docking results?
Alexander Matthew Payne, Benjamin Kaminow, Hugo MacDermott-Opeskin, et al.
Pathogens (Basel, Switzerland)
|
February 25, 2023
Discovery and Development Strategies for SARS-CoV-2 NSP3 Macrodomain Inhibitors
Marion Schuller, Tryfon Zarganes-Tzitzikas, James Bennett, et al.
Nature Communications
|
May 5, 2025
Where and how to house big data on small fragments
Daniel A Erlanson, Stephen K Burley, Daren Fearon, et al.
Proceedings of the National Academy of Sciences of the United States of America
|
March 6, 2023
Turning high-throughput structural biology into predictive inhibitor design
Kadi L Saar, William McCorkindale, Daren Fearon, et al.
Biorxiv : the Preprint Server for Biology
|
April 16, 2025
Crystallographic fragment screening of the dengue virus polymerase reveals multiple binding sites for the development of non-nucleoside antiflavivirals
Manisha Saini, Jasmin C Aschenbrenner, Francesc Xavier Ruiz, et al.
Journal of Medicinal Chemistry
|
September 2, 2025
Crystallographic Fragment Screening of the Dengue Virus Polymerase Reveals Multiple Binding Sites for the Development of Non-nucleoside Antiflavivirals
Manisha Saini, Jasmin C Aschenbrenner, Francesc Xavier Ruiz, et al.
RSC Chemical Biology
|
August 17, 2022
Discovery of novel druggable pockets on polyomavirus VP1 through crystallographic fragment-based screening to develop capsid assembly inhibitors
Evgenii M Osipov, Ali H Munawar, Steven Beelen, et al.
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Search research articles
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Showing results (1-10 of 42) with videos related to
Sort By:
Page
of 5
Bioorganic & Medicinal Chemistry
|
May 17, 2018
Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition
Daren Fearon, Isaac M Westwood, Rob L M van Montfort, et al.
Organic Letters
|
October 20, 2022
Synthesis of a Thiazole Library via an Iridium-Catalyzed Sulfur Ylide Insertion Reaction
Storm Hassell-Hart, Elisa Speranzini, Sirihathai Srikwanjai, et al.
Chemmedchem
|
May 23, 2026
Fragment-Based Design of Targeted Covalent Inhibitors: The Scope and Limitation of Linking Approaches
Levente Kollár, Levente M Mihalovits, Dávid Bajusz, et al.
Biorxiv : the Preprint Server for Biology
|
October 3, 2025
How many crystal structures do you need to trust your docking results?
Alexander Matthew Payne, Benjamin Kaminow, Hugo MacDermott-Opeskin, et al.
Pathogens (Basel, Switzerland)
|
February 25, 2023
Discovery and Development Strategies for SARS-CoV-2 NSP3 Macrodomain Inhibitors
Marion Schuller, Tryfon Zarganes-Tzitzikas, James Bennett, et al.
Nature Communications
|
May 5, 2025
Where and how to house big data on small fragments
Daniel A Erlanson, Stephen K Burley, Daren Fearon, et al.
Proceedings of the National Academy of Sciences of the United States of America
|
March 6, 2023
Turning high-throughput structural biology into predictive inhibitor design
Kadi L Saar, William McCorkindale, Daren Fearon, et al.
Biorxiv : the Preprint Server for Biology
|
April 16, 2025
Crystallographic fragment screening of the dengue virus polymerase reveals multiple binding sites for the development of non-nucleoside antiflavivirals
Manisha Saini, Jasmin C Aschenbrenner, Francesc Xavier Ruiz, et al.
Journal of Medicinal Chemistry
|
September 2, 2025
Crystallographic Fragment Screening of the Dengue Virus Polymerase Reveals Multiple Binding Sites for the Development of Non-nucleoside Antiflavivirals
Manisha Saini, Jasmin C Aschenbrenner, Francesc Xavier Ruiz, et al.
RSC Chemical Biology
|
August 17, 2022
Discovery of novel druggable pockets on polyomavirus VP1 through crystallographic fragment-based screening to develop capsid assembly inhibitors
Evgenii M Osipov, Ali H Munawar, Steven Beelen, et al.
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of 5