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The Journal of Organic Chemistry
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December 3, 2025
Desymmetrization of <i>meso</i>-Anhydride Enabled Enantioselective Synthesis of (-)-7-(Bromomethylene)-3-amidobicyclo[2.2.1]heptane-2-carboxamide, a Scaffold for Divergent Drug Discovery Synthesis
Jianqing Li, Subramaniam Krishnananthan, Daniel Smith, et al.
The Journal of Organic Chemistry
|
April 23, 2024
Challenges with the Synthesis of a Macrocyclic Thioether Peptide: From Milligram to Multigram Using Solid Phase Peptide Synthesis (SPPS)
James Kempson, Rulin Zhao, Joseph Pawluczyk, et al.
Bioorganic & Medicinal Chemistry Letters
|
August 3, 2020
Discovery of (3S,4S)-3-methyl-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxyprop-2-yl)phenyl)pyrrolidines as novel RORγt inverse agonists
Bin Jiang, James J-W Duan, Sylwia Stachura, et al.
Bioorganic & Medicinal Chemistry Letters
|
April 13, 2023
Synthesis and biological evaluation of biaryl alkyl ethers as inhibitors of IDO1
Jay A Markwalder, Aaron J Balog, David K Williams, et al.
The Journal of Organic Chemistry
|
June 14, 2021
A Stereocontrolled Synthesis of a Phosphorothioate Cyclic Dinucleotide-Based STING Agonist
James Kempson, Huiping Zhang, Xiaoping Hou, et al.
Bioorganic & Medicinal Chemistry Letters
|
June 22, 2017
Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase
Barbara Zhizhen Zheng, Stanley V D'Andrea, Umesh Hanumegowda, et al.
Bioorganic & Medicinal Chemistry Letters
|
July 2, 2019
Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as RORγt inverse agonists
Zhonghui Lu, James J-W Duan, Haiyun Xiao, et al.
Bioorganic & Medicinal Chemistry Letters
|
June 9, 2023
Discovery of novel pyridinones as MGAT2 inhibitors for the treatment of metabolic disorders
Fang Moore, Wei Wang, Guohua Zhao, et al.
ACS Medicinal Chemistry Letters
|
November 20, 2024
Invention of VH-937, a Potent HIV-1 Maturation Inhibitor with the Potential for Infrequent Oral Dosing in Humans
Sing-Yuen Sit, Yan Chen, Jie Chen, et al.
ACS Medicinal Chemistry Letters
|
March 21, 2019
Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists
James J-W Duan, Zhonghui Lu, Bin Jiang, et al.
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of 7
Search research articles
Search
Showing results (21-30 of 62) with videos related to
Sort By:
Page
of 7
The Journal of Organic Chemistry
|
December 3, 2025
Desymmetrization of <i>meso</i>-Anhydride Enabled Enantioselective Synthesis of (-)-7-(Bromomethylene)-3-amidobicyclo[2.2.1]heptane-2-carboxamide, a Scaffold for Divergent Drug Discovery Synthesis
Jianqing Li, Subramaniam Krishnananthan, Daniel Smith, et al.
The Journal of Organic Chemistry
|
April 23, 2024
Challenges with the Synthesis of a Macrocyclic Thioether Peptide: From Milligram to Multigram Using Solid Phase Peptide Synthesis (SPPS)
James Kempson, Rulin Zhao, Joseph Pawluczyk, et al.
Bioorganic & Medicinal Chemistry Letters
|
August 3, 2020
Discovery of (3S,4S)-3-methyl-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxyprop-2-yl)phenyl)pyrrolidines as novel RORγt inverse agonists
Bin Jiang, James J-W Duan, Sylwia Stachura, et al.
Bioorganic & Medicinal Chemistry Letters
|
April 13, 2023
Synthesis and biological evaluation of biaryl alkyl ethers as inhibitors of IDO1
Jay A Markwalder, Aaron J Balog, David K Williams, et al.
The Journal of Organic Chemistry
|
June 14, 2021
A Stereocontrolled Synthesis of a Phosphorothioate Cyclic Dinucleotide-Based STING Agonist
James Kempson, Huiping Zhang, Xiaoping Hou, et al.
Bioorganic & Medicinal Chemistry Letters
|
June 22, 2017
Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase
Barbara Zhizhen Zheng, Stanley V D'Andrea, Umesh Hanumegowda, et al.
Bioorganic & Medicinal Chemistry Letters
|
July 2, 2019
Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as RORγt inverse agonists
Zhonghui Lu, James J-W Duan, Haiyun Xiao, et al.
Bioorganic & Medicinal Chemistry Letters
|
June 9, 2023
Discovery of novel pyridinones as MGAT2 inhibitors for the treatment of metabolic disorders
Fang Moore, Wei Wang, Guohua Zhao, et al.
ACS Medicinal Chemistry Letters
|
November 20, 2024
Invention of VH-937, a Potent HIV-1 Maturation Inhibitor with the Potential for Infrequent Oral Dosing in Humans
Sing-Yuen Sit, Yan Chen, Jie Chen, et al.
ACS Medicinal Chemistry Letters
|
March 21, 2019
Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists
James J-W Duan, Zhonghui Lu, Bin Jiang, et al.
Page
of 7