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David A Sykes

Showing results (1-10 of 46) with videos related to

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Methods in Molecular Biology (Clifton, N.J.)|July 25, 2018
Single Step Determination of Unlabeled Compound Kinetics Using a Competition Association Binding Method Employing Time-Resolved FRETDavid A Sykes, Steven J Charlton
British Journal of Pharmacology|September 3, 2011
Slow receptor dissociation is not a key factor in the duration of action of inhaled long-acting β2-adrenoceptor agonistsDavid A Sykes, Steven J Charlton
Molecular Pharmacology|August 23, 2019
Investigating the Influence of Tracer Kinetics on Competition-Kinetic Association Binding Assays: Identifying the Optimal Conditions for Assessing the Kinetics of Low-Affinity CompoundsDavid A Sykes, Palash Jain, Steven J Charlton
Molecular Pharmacology|June 6, 2009
Exploring the mechanism of agonist efficacy: a relationship between efficacy and agonist dissociation rate at the muscarinic M3 receptorDavid A Sykes, Mark R Dowling, Steven J Charlton
Current Protocols in Pharmacology|February 2, 2012
Measuring receptor target coverage: a radioligand competition binding protocol for assessing the association and dissociation rates of unlabeled compoundsDavid A Sykes, Mark R Dowling, Steven J Charlton
Molecular and Cellular Endocrinology|February 11, 2019
Binding kinetics of ligands acting at GPCRsDavid A Sykes, Leigh A Stoddart, Laura E Kilpatrick, et al.
Methods in Molecular Biology (Clifton, N.J.)|March 1, 2020
GPCR Solubilization and Quality ControlTamara Miljus, David A Sykes, Clare R Harwood, et al.
Molecular Pharmacology|January 31, 2014
Observed drug-receptor association rates are governed by membrane affinity: the importance of establishing "micro-pharmacokinetic/pharmacodynamic relationships" at the β2-adrenoceptorDavid A Sykes, Cheryl Parry, John Reilly, et al.
Nature Communications|September 5, 2018
Reply to 'Antipsychotics with similar association kinetics at dopamine D<sub>2</sub> receptors differ in extrapyramidal side-effects'David A Sykes, J Robert Lane, Monika Szabo, et al.
Pharmacology Research & Perspectives|June 28, 2022
Exploring the kinetic selectivity of drugs targeting the β<sub>1</sub> -adrenoceptorDavid A Sykes, Mireia Jiménez-Rosés, John Reilly, et al.
Pageof 5

Showing results (1-10 of 46) with videos related to

Sort By:
Pageof 5
Methods in Molecular Biology (Clifton, N.J.)|July 25, 2018
Single Step Determination of Unlabeled Compound Kinetics Using a Competition Association Binding Method Employing Time-Resolved FRETDavid A Sykes, Steven J Charlton
British Journal of Pharmacology|September 3, 2011
Slow receptor dissociation is not a key factor in the duration of action of inhaled long-acting β2-adrenoceptor agonistsDavid A Sykes, Steven J Charlton
Molecular Pharmacology|August 23, 2019
Investigating the Influence of Tracer Kinetics on Competition-Kinetic Association Binding Assays: Identifying the Optimal Conditions for Assessing the Kinetics of Low-Affinity CompoundsDavid A Sykes, Palash Jain, Steven J Charlton
Molecular Pharmacology|June 6, 2009
Exploring the mechanism of agonist efficacy: a relationship between efficacy and agonist dissociation rate at the muscarinic M3 receptorDavid A Sykes, Mark R Dowling, Steven J Charlton
Current Protocols in Pharmacology|February 2, 2012
Measuring receptor target coverage: a radioligand competition binding protocol for assessing the association and dissociation rates of unlabeled compoundsDavid A Sykes, Mark R Dowling, Steven J Charlton
Molecular and Cellular Endocrinology|February 11, 2019
Binding kinetics of ligands acting at GPCRsDavid A Sykes, Leigh A Stoddart, Laura E Kilpatrick, et al.
Methods in Molecular Biology (Clifton, N.J.)|March 1, 2020
GPCR Solubilization and Quality ControlTamara Miljus, David A Sykes, Clare R Harwood, et al.
Molecular Pharmacology|January 31, 2014
Observed drug-receptor association rates are governed by membrane affinity: the importance of establishing "micro-pharmacokinetic/pharmacodynamic relationships" at the β2-adrenoceptorDavid A Sykes, Cheryl Parry, John Reilly, et al.
Nature Communications|September 5, 2018
Reply to 'Antipsychotics with similar association kinetics at dopamine D<sub>2</sub> receptors differ in extrapyramidal side-effects'David A Sykes, J Robert Lane, Monika Szabo, et al.
Pharmacology Research & Perspectives|June 28, 2022
Exploring the kinetic selectivity of drugs targeting the β<sub>1</sub> -adrenoceptorDavid A Sykes, Mireia Jiménez-Rosés, John Reilly, et al.
Pageof 5