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David B Smith

Showing results (41-50 of 58) with videos related to

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Journal of Medicinal Chemistry|April 6, 2019
Synthesis and Anti-HCV Activities of 4'-Fluoro-2'-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4'-Fluoro-2'- C-methyluridine 5'-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C InfectionGuangyi Wang, Natalia Dyatkina, Marija Prhavc, et al.
International Journal of Molecular Sciences|November 25, 2023
Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy ModelsAndreas Jekle, Santosh Kumar Thatikonda, Ruchika Jaisinghani, et al.
Journal of Medicinal Chemistry|August 21, 2020
Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of <b>AL-611</b> as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis CGuangyi Wang, Natalia Dyatkina, Marija Prhavc, et al.
Journal of Medicinal Chemistry|December 6, 2008
The design, synthesis, and antiviral activity of 4'-azidocytidine analogues against hepatitis C virus replication: the discovery of 4'-azidoarabinocytidineDavid B Smith, Genadiy Kalayanov, Christian Sund, et al.
Journal of Medicinal Chemistry|April 4, 2009
The design, synthesis, and antiviral activity of monofluoro and difluoro analogues of 4'-azidocytidine against hepatitis C virus replication: the discovery of 4'-azido-2'-deoxy-2'-fluorocytidine and 4'-azido-2'-dideoxy-2',2'-difluorocytidineDavid B Smith, Genadiy Kalayanov, Christian Sund, et al.
The Journal of Biological Chemistry|December 1, 2005
The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell cultureKlaus Klumpp, Vincent Lévêque, Sophie Le Pogam, et al.
The New England Journal of Medicine|July 11, 2006
Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancerDavid Cunningham, William H Allum, Sally P Stenning, et al.
Structure (London, England : 1993)|February 6, 2026
Structural basis for pan-coronavirus inhibition of 3CL proteaseEswar R Reddem, Farhad Forouhar, Cheng Liu, et al.
The Journal of Biological Chemistry|November 16, 2007
2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groupsKlaus Klumpp, Genadiy Kalayanov, Han Ma, et al.
Bioorganic & Medicinal Chemistry Letters|February 24, 2007
Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479David B Smith, Joseph A Martin, Klaus Klumpp, et al.
Pageof 6

Showing results (41-50 of 58) with videos related to

Sort By:
Pageof 6
Journal of Medicinal Chemistry|April 6, 2019
Synthesis and Anti-HCV Activities of 4'-Fluoro-2'-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4'-Fluoro-2'- C-methyluridine 5'-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C InfectionGuangyi Wang, Natalia Dyatkina, Marija Prhavc, et al.
International Journal of Molecular Sciences|November 25, 2023
Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy ModelsAndreas Jekle, Santosh Kumar Thatikonda, Ruchika Jaisinghani, et al.
Journal of Medicinal Chemistry|August 21, 2020
Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of <b>AL-611</b> as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis CGuangyi Wang, Natalia Dyatkina, Marija Prhavc, et al.
Journal of Medicinal Chemistry|December 6, 2008
The design, synthesis, and antiviral activity of 4'-azidocytidine analogues against hepatitis C virus replication: the discovery of 4'-azidoarabinocytidineDavid B Smith, Genadiy Kalayanov, Christian Sund, et al.
Journal of Medicinal Chemistry|April 4, 2009
The design, synthesis, and antiviral activity of monofluoro and difluoro analogues of 4'-azidocytidine against hepatitis C virus replication: the discovery of 4'-azido-2'-deoxy-2'-fluorocytidine and 4'-azido-2'-dideoxy-2',2'-difluorocytidineDavid B Smith, Genadiy Kalayanov, Christian Sund, et al.
The Journal of Biological Chemistry|December 1, 2005
The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell cultureKlaus Klumpp, Vincent Lévêque, Sophie Le Pogam, et al.
The New England Journal of Medicine|July 11, 2006
Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancerDavid Cunningham, William H Allum, Sally P Stenning, et al.
Structure (London, England : 1993)|February 6, 2026
Structural basis for pan-coronavirus inhibition of 3CL proteaseEswar R Reddem, Farhad Forouhar, Cheng Liu, et al.
The Journal of Biological Chemistry|November 16, 2007
2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groupsKlaus Klumpp, Genadiy Kalayanov, Han Ma, et al.
Bioorganic & Medicinal Chemistry Letters|February 24, 2007
Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479David B Smith, Joseph A Martin, Klaus Klumpp, et al.
Pageof 6