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Science Translational Medicine|August 4, 2017
Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancerDelphine Merino, James R Whittle, François Vaillant, et al.
Cancer Discovery|December 6, 2018
Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic LeukemiaPiers Blombery, Mary Ann Anderson, Jia-Nan Gong, et al.
Nature Communications|October 15, 2017
NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expressionJunyi Ju, Aiping Chen, Yexuan Deng, et al.
Nature Chemical Biology|April 23, 2013
Structure-guided design of a selective BCL-X(L) inhibitorGuillaume Lessene, Peter E Czabotar, Brad E Sleebs, et al.
Science Advances|March 5, 2025
Differential regulation of BAX and BAK apoptotic activity revealed by small moleculesKaiming Li, Yu Q Yap, Donia M Moujalled, et al.
Blood|June 16, 2022
Single-cell multiomics reveal the scale of multilayered adaptations enabling CLL relapse during venetoclax therapyRachel Thijssen, Luyi Tian, Mary Ann Anderson, et al.
Cell Death and Differentiation|April 9, 2025
Re-appraising assays on permeabilized blood cancer cells testing venetoclax or other BH3 mimetic agents selectively targeting pro-survival BCL2 proteinsJia-Nan Gong, Tirta M Djajawi, Donia M Moujalled, et al.
Blood|October 11, 2022
Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemiaDonia M Moujalled, Fiona C Brown, Chong Chyn Chua, et al.
Journal of Medicinal Chemistry|June 18, 2013
Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XLBrad E Sleebs, Wilhemus J A Kersten, Sanji Kulasegaram, et al.
ACS Chemical Biology|September 9, 2020
Potent Inhibition of Necroptosis by Simultaneously Targeting Multiple Effectors of the PathwayCatia L Pierotti, Maria C Tanzer, Annette V Jacobsen, et al.
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